Chapter 347 BOLD-FMRI [seeking a monthly ticket
Was, the checking bed moved to the circular magnet, Gu Jun did not move, relaxed his mind, and thought nothing, let the equipment take a picture of his comparison status first.
While the fmri machine is running, it is set in front of the operating table in the front room. Professor Ma, Dr. Chen and others are all looking at the image pictures on several computer screens.
At this time, the blood flow in Gu Jun's brain is displayed in the image, but only professionals can understand what the signal means of different colors and color brightness in different brain regions, as well as the information disclosed by parameters such as mr value, te value, t2 value, etc.
Not to mention Wu Shiyu, Cai Zixuan can only sigh at the sight of the picture.
"Ajun's condition is normal." Dr. Chen said to them.
After a while, after entering enough comparison status image data, Professor Ma said to Gu Jun through the speaker in the examination room: "Ajun, next do the stimulation task, from light to heavy. First of all, I will speak the terms of abnormal things, listen carefully. If you feel a headache, don't endure it. Use your screams to let us know the severity of your situation. If you can't stand it, be sure to ask me to stop immediately."
"Okay." Gu Jun in the examination room responded, "Professor Ma, you can start."
Professor Ma calmly looked middle-aged and began to slowly say names one by one with great confidence: "Spell, deep diving, strange banyan disease, strange banyan tree in human body..."
As Professor Ma said, the brightness of the color of the brain images on the screen suddenly increased, and Gu Jun's brain activity became more active.
"Scale disease, ritual, Dagon, Tian Yiqing..." The more Professor Ma said, the brighter the image became, and the more nervous everyone was.
"Ah!" Gu Jun suddenly let out a scream of pain. He felt the pain in his head changed from a hidden pain to a burst of severe pain, which made his body feel a little stiff.
This is his stress state, and it is also the task state for this check. By subtracting the blood flow diagram of the task state from the blood flow diagram of the control state, it is possible to find brain parts related to the unique psychological operations in the task state, and now an instant comparison result is displayed on a screen.
Dr. Chen naturally understood the image. He frowned at the sight and whispered to Wu Shiyu and the others: "The blood flow in the frontal lobe, amygdala, hippocampus, and these three places has increased significantly."
Cai Zixuan couldn't help but sigh and grabbed his bald forehead. It would be not a good thing if it was these three places...
He has read some research literature on PTTSD. One of the main research results of PTTSD's brain imaging is to find that the patient's hippocampus, parahippocampal gyrus, amygdala, prefrontal lobe, etc. have abnormal functions, so there is the pathological hypothesis of "prefrontal lobe-amyogdala-hippocampal circuit".
That is, the prefrontal lobe damage leads to weakening of function, thereby weakening its regulatory and control effect on the amygdala, which makes the amygdala overreact to terrorism. The damage to the hippocampus itself and the dysregulation of the connection with the prefrontal lobe and amygdala are also involved in the damage process of patient memory.
The current measurement of Hao Jun's blood flow change is consistent with the typical manifestation of local brain activity in this hypothesis.
The location of Hao Jun's cerebral hemorrhage was the right frontal lobe. If the injury and related surgery caused abnormal prefrontal lobe function, the cause will be found.
"Ajun, now increase the excitement. Think about what happened on that small island." Professor Ma said again, "Stop if you can't stand it, don't force it."
Gu Jun followed the stimulation task and his head hurt so much that he was so unbearable that he breathed into breathing.
Next was the most serious task. The nurse next to the FMRI machine gave him a document, all of which were pictures of abnormal things like the corpse of a deep diving person, a patient with a banyan disease. Gu Jun only saw two or three pictures, and his head hurt so severely that his muscles involuntarily twitched before the epilepsy seizure. He immediately closed his eyes and stopped.
The stimulation task of this examination ended, but Gu Jun did not leave the examination bed for the time being, and asked the machine to continue recording the changes in the brain blood flow during his recovery process.
On the other hand, Professor Ma and Dr. Chen looked at the comparison images on the computer, and their faces became more and more ugly, and they were a little surprised...
When Gu Jun recalled the traumatic scene, the blood flow continued to increase; and when he watched the stress picture, he experienced hemodynamic changes, not only the prefrontal lobe, amygdala and hippocampus, but also the blood flow in the whole brain increased dramatically. This physiological reaction is much stronger than that of ordinary patients with PTTSD.
Moreover, such rapid congestion in the whole cerebral is very dangerous, which will lead to sudden increase in blood pressure, which can easily cause rupture of the microvascular in the brain and cause bleeding.
Considering that Gu Jun also has a history of cerebral hemorrhage and craniotomy, this level of stress is enough to be fatal to him.
"It's not optimistic, it's really not optimistic..." Dr. Chen murmured. He was not a pessimistic person, but he felt helpless at this time.
After Gu Jun came out of the examination room, he saw their expressions and knew that the situation was not optimistic.
When he looked at the images, he felt a little confused. Is the dysfunction caused by the prefrontal lobe damage? This is difficult to treat...
"Xian Jun." Wu Shiyu patted his shoulder, "You were still in a coma half a month ago, so you will get better slowly."
"Yes." Gu Jun nodded to her and said to Professor Ma: "Professor Ma, I want to do the mri and mrs, and find out more clearly."
MRI is a nuclear magnetic resonance, which is used in brain function examination, and MRS is a brain morphology measurement, while MRS is a living magnetic resonance spectroscopy measurement, which can measure the volume of the hippocampus and evaluate whether there is any loss or damage to hippocampal neurons. Because changes in hippocampal structure are typical symptom of patients with PTTSD.
For both tests, you need to inject radioactive substances, that is, contrast agents, which were not easy to use due to concerns to his body.
Now it was Gu Jun's request and Bold-FMRI could not indicate the structure of his hippocampus. After discussing with Dr. Shen, Professor Ma agreed to conduct the examination, but first asked Gu Jun to rest in the laboratory for three hours. Then the nurse gave him contrast agent, and then he completed the MRI and MRS examinations one after another.
mri is anatomical image, while mrs is a combination of all chemical signals recorded in the subject being tested, and the measurement results are spectral diagrams of multiple spectral lines.
Gu Jun's MRI image showed indirect signs of the reduction in hippocampus size - his lateral ventricle temporal horn enlarged and the shallow sulcus on the head of the hippocampus disappeared.
MRS results also show that there is a signal of a decrease in the number of hippocampal neurons.
On this day, Gu Jun also did some other tests, such as blood test for bdnf level (brain-derived neurotrophic factor). The bdnf level of ptsd patients is usually lower than that of normal people. Now his bdnf level is relatively low, which is even more dramatically lower than the results of the last physical examination.
Research data from the Tianji Bureau shows that the BDNF level of high-spirited people will be higher than that of normal people, which may also be the source of its spiritual knowledge.
Now Gu Jun seems to have not only lost his Gao Lingzhi, but also had neuroendocrine characteristics of ptsd pathology.
All these examination results were put together, Professor Ma and the others knew what the answer was... Gu Jun's brain shape did change.
"Ajun, you go back and have a good rest first and relax. Don't think so much. We will discuss a treatment plan that is most suitable for you." Dr. Chen pretended to comfort him easily and sent Gu Jun and the other two out of the laboratory.
Then, Dr. Chen and Professor Ma came to the conference room next to hold a remote meeting. Tongye, Yao Shinian, the director and others were all waiting for the inspection report.
Robot Wali says
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Chapter completed!