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Chapter 514 The mystery of aging, the MTOR gene signaling pathway!

Luo Jia picked up the ink pen that had been prepared, wrote on the whiteboard in the conference room, and wrote down many complex and mysterious codes. The Wen brothers glanced at it and knew that those were genetic codes.

On the other hand, Wen Chengfeng cleared his throat and began to summarize the recent work of the Department of Life Sciences. Luo Jia showed great trust in them, never urged the research progress, and even did not come to inspect it for several months. But since Luo Jia has arrived this time, he always has to report to the boss, which is normal.

"In the past six months, the largest research result of the Department of Life Sciences has clarified some issues related to human lifespan. First of all, can humans live longer?"

Wen Chengfeng glanced at Luo Jia, "The answer is yes. Of course, humans may have a very long lifespan, because as we all know, our somatic cells are metabolizing every moment."

"Take the superficial skin that women pay most attention to, it takes 14 days for keratinocytes to die from birth to death. If the division cycle is included, the entire cycle of skin metabolism will be forty-one to forty-seven days."

"Depending on age, the metabolism rate will also vary. Young people have short metabolic cycles, while older people have longer metabolic cycles."

"That is to say, it only takes forty-seven days at most, and our faces are no longer the faces of the past, but have changed into a new face through cell metabolism."

"Of course, cell-level metabolism is a microscopic change. From the outside, everything seems to be the same. However, compared with 47 days ago, the cells that make up the epidermis of the face have been replaced with a batch of new ones. This is an unquestionable fact."

Luo Jia nodded slightly. Humans are composed of cells, and cell renewal is underway at all times. From the perspective of cells, you were yesterday and you today are actually different.

Wen Chengfeng continued: "The lifespan of liver cells is only five months, and they will die and renew. Even our bones will complete a round of cell changes every ten years. After middle age, the bone renewal speed slows down, so osteoporosis is formed. Therefore, the elderly are prone to fracture after falling. The fundamental reason is not that the bones become fragile, but that the metabolism of our elderly is slowing down."

"It can be seen that if we can control the speed of metabolism, it is equivalent to turning on the code of life span. Human metabolism is controlled through genes. What we are doing is to find and control the set of genes about life span."

"At present, the only way we have determined to open the correct way of longevity is called calorie restriction. The energy limit is simply to eat less and eat 70% full every time we eat."

"We tried in humans, mice, cells, and almost all species, and by controlling diet and reducing calorie intake, we finally achieved success..."

Wen Chengfeng introduced a lot to Luo Jia, from the past to the present, everything is very detailed. When he talked about the lab setting eighteen standards for aging, Luo Jia focused on the key points and felt that it was an extremely correct decision to hand over the Ministry of Life Sciences to the Wen brothers.

Science is not a joke, it requires strict and quantitative standards.

Luo Jia forgot to see it in an online novel. The novel mentions a technology, life-extending technology, how to prolong life? Anyway, it makes people look very young.

Looks young...

Alas, Luo Jia is really unable to complain about this idealistic subjective description.

The specific set of standards set by the Wen brothers include the following items:

1 glycoprotein.

2 Breathe vigorously within one second.

3Artificial blood pressure.

4 Total cholesterol.

5 reactive protein.

6 Creatinine clearance.

7 Urea nitrogen.

8. Heart and lung fitness.

9 waist-to-hip ratio.

10 Maximum lung capacity ratio.

11 Body mass index.

12 leukocyte telomeres length.

13 lipoprotein.

14 triglycerides.

15 Periodontitis.

16 white blood cell count,.

17 high-density lipoprotein.

18 apolipoprotein ratio.

This is the correct attitude towards science. In order to study anti-aging, they first used eighteen rigorous data to define what aging is. Along with this standard, there is also a set of algorithms and mathematical models to input personal indicators to obtain the current aging coefficient.

"This is the current research status of the Department of Life Sciences." Wen Chengfeng concluded: "We have done a lot of research, defined the standards for aging, and found some organ-level metabolic control technologies. For example, we have achieved quite good results in metabolic management of surface skin. The company's cosmetics department swept the world and obtained amazing amounts of wealth from female consumers who love beauty, and these wealth eventually turned into space elevators and became scientific research funds for our department."

"To be honest, I was a little scared. In order to smooth out a few crow's feet at the corners of my eyes, women were willing to pay such a high price? This is unscientific! Isn't it just a few wrinkles? Are they so troubling?"

After hearing Wen Chengfeng's complaints, Luo Jia almost laughed out loud. The straight male aura in the company was too serious. The Wen brothers were all in their forties and were quite old, but they were still very upright.

Unscientific?

When did a creature like a woman have been scientific?

Luo Jia coughed lightly, stood up, and came to the whiteboard, "I have already learned about the specific situation. The Department of Life Sciences has done a good job. In short, I feel at 120 of you."

"Next, I want to talk about my discovery in my spare time. Since the development of distributed supercomputing and artificial intelligence, the threshold for scientific research has been greatly reduced. Not only can I build models myself, do gene deductions, but I can even have junior high school students and primary school students who have some knowledge of genetic science, but I can also engage in research that I am interested in, and simulate gene evolution and the path to take effect on supercomputing."

China's distributed supercomputing system is now becoming more and more awesome. The country's networking and computing power has been rising rapidly, and it has reached the level of being open to all individual users. Any Chinese citizen can use supercomputing resources to engage in scientific research.

Of course, there is still a big gap between ideals and reality. According to statistics from the Supercomputing Administration, the biggest application of Huaxia distributed supercomputing system is game computing, and the second largest is CG rendering.

In other words, instead of doing research, everyone used supercomputer resources to develop games and rendered them later for movies and animations, making the pictures of the small movies clearer and more tingling and trembling.

Luo Jia is not against games. He also played games a lot back then. The key is that games require grading and restrictions. As long as young people are not addicted to it, they play games for two hours a day, Luo Jia is not against it.

As for the small movies becoming clearer, Luo Jia didn't say it, but actually gave a secret praise in her heart. High-definition small movies combined with panoramic VR are a good thing, whoever watches them will know.

Luo Jia explained to the Wen brothers that he was doing life science research in his spare time. If you come up with a scary conclusion later, you don’t have to doubt that it is not that I have any special features, it is all due to the popularity of supercomputers. Luo Jia has always been very careful in concealing the truth about the golden dome.

Luo Jia pointed to a line of words he wrote on the whiteboard earlier and said, "mammalian target of rapamycin, mammalian rapamycin target, referred to as MTOR."

"MTOR is a class of threonine kinase. The C-terminus is homologous to phosphatidylinositol kinase, but it does not have the activity of esterase kinase, but protein kinase activity. I deduced MTOR through supercomputing and found some very strange phenomena. It seems that the gene signaling pathway of MTOR has the effect of controlling substance metabolism and cell autophagy."

After hearing Luo Jia's opening, the Wen brothers were stunned and cheered up.

"Impossible! Could it be that Mr. Luo found a gene pathway that controls metabolism and cell autophagy!?"

The Wen brothers cried in their hearts, and they were all shocked. The genetic signaling pathway is actually not new. Scientists discovered it as early as 1972.

Simply put, it is to use protein kinase and phosphatase as signal transmission substances, and finally issue an order to the cell, telling the cell that it should divide and proliferate, that you are already aging, don’t stand in a pit and don’t poop, hurry up and count the ball, etc.

You can order your child to wash his hands before eating, but you can't order your child to grow taller quickly, at least 1.8 meters tall, and have charming small eyes and long legs like Korean Oppa.

However, the gene signaling pathway can be done because it can directly issue commands to cells. Cells calculated in hundreds of billions of dollars are the most basic units in the human body. Changes in cells will eventually lead to global changes.

Since the gene signaling pathway is so awesome, why don’t we try to write about human genes to prevent aging and make everyone grow long legs?

The reason is very simple, it is really difficult.

The human gene map consists of 250,000 genes and 3 billion bases, and the number is too large.

However, if you think this is the whole of human genes, you can only say that you are still too naive.

In addition to those above, there are more than one million bacterial genes in the human body, because there are about one million cells from other organisms in the human body.

In other words, ninety percent of the cells in our body do not actually belong to us. Our body is actually composed of bacterial flora and some human cells attached to it.

In the process of billions of years of evolution, our body cells and millions of microorganisms have symbiotically coexisted. Microorganisms have affected the evolution of each of our organs, including the brain and heart. The DNA of microorganisms has long penetrated into human DNA. The DNA of microorganisms has long become an integral part of human DNA!

Some people say that humans are the most complex existence in nature, and from a genetic perspective, this statement is correct.

Human genes are really complex. It is almost impossible to complete the task to find a path to completely control aging in such a complex gene sequence, and even developed extraterrestrial civilizations cannot do it.

The MTOR pathway provided by Lan Yu to Luo Jia is not a complete life control, but to a certain extent, controlling metabolism and cellular autophagy. The 2016 Nobel Prize in Biology and Medicine was issued to the discoverers of the principle of cellular autophagy. It can be seen that the research on the gene field of Earthlings is just in its infancy.

However, today, Luo Jia came to the Wen brothers' laboratory and brought them a gene signaling pathway that could control metabolism and cell autophagy, which made the Wen brothers so excited that they tremble all over!

They couldn't believe what kind of luck was that Luo Jia accidentally discovered a gene signaling pathway that might be controlled by aging in her spare time!?

After the introduction, the Wen brothers were stunned. Luo Jia gently lowered the ink pen and shrugged, "I am an amateur about the issue in the field of life sciences, but according to the results of the supercomputing model deduction, MTOR, a gene signaling pathway, may ultimately control the speed of cell metabolism and trigger cell autophagy."

"I wonder, if I update all the aging cells in the body through the principle of autophagy, wouldn't it be equivalent to the Yijing marrow cleaning in martial arts novels and reborn? It seems to be very confusing. Why don't you try it a little according to this genetic pathway?"

After hearing Luo Jia's words, the Wen brothers stared at each other.

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