Chapter 349 You should use this bone resorption inhibitor (Part 2)
Wei Kang also saw the news about NASA on the Internet, but he didn't take it to heart. He just found it a bit ridiculous.
He suddenly had the feeling that his eyes were opened. It turned out that bureaucrats all over the world had similar faces when they defrauded funds.
It is not news that many institutions in Eagle Country purchase equipment from the East, directly remodel it, put on the appearance and branding of compliance, and then use it blatantly.
Unexpectedly, NASA, which claims to be the temple of science and technology, has also fallen. It is no different from other agencies. It still engages in this kind of business of selling sheep over dogs and falsely promoting it as its own technology. It is simply laughable.
Thinking of this, he couldn't help but shake his head in disappointment. Compared with the China Space Center, this kind of NASA is simply far behind. It can't even seek truth from facts. How can it gallop in the ocean of science and technology, and how can it go towards the sea of stars?
.
At this moment, the phone suddenly rang.
At first glance, it was Fang Heng from the Space Center.
Fang Heng came here to announce the good news: "Mr. Wei, good news, the portable universal monitor is very successful. The space center wants to reach a long-term strategic partnership with Sanqing. In the future, in the space medical field, whether it is drugs or equipment, we must
Strengthen cooperation.”
Wei Kang was very happy to hear this. This is indeed good news. In this case, any medical devices developed in the future can be directly displayed and promoted on the space station. At the same time, it will be more closely tied to the country's aerospace field.
As far as the Three Purities are concerned, it is true that there are hundreds of benefits and no harm.
Now when there is only one device, it is not obvious. When more medical devices are developed in the future, especially some high-end large-scale equipment, they can be tried out in a place like the space station, which will give people a much more powerful feeling than trying them out in a hospital.
If the results are good, it is equivalent to a level of endorsement. When it is promoted to other public hospitals in the future, it will definitely be more convincing.
So he immediately agreed, and soon after, the two sides talked about in-depth cooperation in medicine.
Due to the influence of a series of factors such as strong radiation in space, weightless environment, storage conditions, etc., the efficacy of many drugs will decrease significantly after traveling in space, and many drugs will not meet the prescribed efficacy requirements.
Correspondingly, the shelf life has also been greatly reduced, generally 6-12 months, which is much shorter than the two or three years of ordinary drugs.
In the space station, the activity of many bacteria and viruses can often be greatly improved, and even mutate to a certain extent.
Therefore, the space center wants to conduct research on medicine and genetics together with Sanqing.
Not only can we extend the efficacy and shelf life of some common drugs, but we can also use the space environment to study the genetic variation of organisms.
Sanqing Group has an excellent reputation in the manufacturing and research and development of original drugs and generic drugs, making it the best partner to seek cooperation with. Not to mention, many of the drugs themselves are produced by Sanqing.
As for the biological field, brand-new gene editing technology and gene therapy are Sanqing’s strengths.
"Due to the needs of space travel, such as the three-year journey to Mars and the construction of a lunar base in the future, our current frequent supply model of drugs is not realistic. The long-term demand for drugs must be taken into consideration and reach space as far as possible.
Be self-sufficient."
"Currently, the shelf life of most drugs on the market cannot meet the requirements of space travel. Producing drugs on demand in space may be the best solution to this challenge."
"So we plan to start with some of the simplest drugs and study the effects of microgravity environment and space radiation on the stability of tablet formulations. Radiation protection will be incorporated into the design of the tablets."
Fang Heng talked eloquently and told everything about the space center's plans.
"The first batch of drugs not only contain active ingredients such as ibuprofen and vitamin C, but also excipients such as silica, magnesium silicate and calcium phosphate, which can be found on the surface of the moon."
"Our plan is to change the interaction between ingredients and drugs to understand the impact of these changes on drug stability."
"If data on drug stability can be collected for long-term space missions, it will help in the future to produce drugs on demand in orbit."
"This is an 'automated airborne pharmaceutical' project. It has just been established and has not officially started yet. However, with your participation, it will surely become even more powerful and progress rapidly."
Wei Kang couldn't help but feel excited. The unique microgravity environment in the space station can enable some scientific research that is limited by the earth's gravity to develop and achieve new breakthroughs.
This is also very important for the fields of life sciences and biotechnology.
During the more than 20 years since the International Space Station was in orbit, a total of more than 3,000 scientific research projects in various disciplines have been conducted, with the highest proportion being biological sciences.
It is a pity that China in the past was completely isolated from this research field.
There is neither a space station nor a pharmaceutical giant, and there are no conditions to carry out research in the fields of space medicine and biology.
Now, with Sanqing Pharmaceutical and the Tiangong Space Station, the conditions are very mature and we can catch up and accelerate research in the field of life sciences in space.
Not only is it worth trying in the biological field, but even some star-level blockbuster new drugs have contributions from space experiments.
Many large molecule drugs face many technical problems in manufacturing, delivery and storage, which are expected to be solved by improving crystallization and purification technology.
Merck researchers have cooperated with the International Space Station and conducted crystallization experiments using macromolecular drugs during commercial supply service space missions.
They used microgravity experiments to study the effects of sedimentation rate and temperature gradient on crystallization purification.
It was found that under microgravity conditions, settling and convection were reduced, resulting in a crystalline suspension that had a lower viscosity and was more homogeneous than the control group on the ground.
Later, the research team used a rotating mixer to control variables such as sedimentation rate and temperature gradient to induce nucleation and control crystallization, successfully replicating a uniform crystalline suspension in space in ground experiments.
This is of great significance to the purification and storage of macromolecular drugs. If it can be widely used, macromolecular drugs will be converted from intravenous injection to subcutaneous injection, which can greatly improve the quality of life of patients.
In addition, the space environment can also provide meaningful data for clinical trials, provide comparison for trials on the ground, and become a perfect reference.
Now, he has a ready-made new drug in his hands that is perfectly suitable for physical problems caused by the space environment.
Thinking of this, Wei Kang glanced at the table and picked up an experimental report.
This is a clinical phase I experimental report of a bone resorption inhibitor.
Data show that this new drug can inhibit bone resorption and has a strong therapeutic effect on osteoporosis and other related diseases.
As for the disease of osteoporosis, no one has experienced it more deeply than astronauts.
In space, astronauts are exposed to microgravity conditions for a long time, and their bodies will undergo a series of changes, which can induce some potential diseases. The most prominent problem is osteoporosis.
Under normal circumstances, bones maintain a balance of bone mass through the interaction of bone formation and bone resorption.
However, in a microgravity environment, because bones no longer need to resist gravity, the reduction in load will lead to increased bone resorption, leading to osteoporosis.
While physical activity can provide relief, it does not completely eliminate the risk.
The whole process is very fast, and it often takes a few weeks to cause osteoporosis in astronauts. Unlike on the ground, osteoporosis is rare in young people and more common in the elderly.
There is no doubt that astronauts who are strong and resilient will be very suitable candidates for drug testing.
The space environment is also a perfect place for clinical trials.
Healthy people will develop symptoms of osteoporosis within a few weeks of treatment. You can test the effectiveness of the medicine while taking it.
You can recover quickly after taking it off, so you don’t have to worry about the sequelae.
Isn’t this better than what an old lady in her 60s can do?
The moment this idea came up, Wei Kang said it directly to his mobile phone.
He can be sure that the other party will definitely be interested.
"There is a new drug, a bone resorption inhibitor for osteoporosis. I think you should use it."
"I wonder if your astronauts are willing to give it a try?"
Chapter completed!