"Wasn't the patient well before I went on vacation? Why did he suddenly get hospital flu?"

Jian Jian Yun's voice became sharp, and his tone was full of anxiety.

"The patient is over 60 years old and had a craniotomy for cerebral hemorrhage. Logically speaking, he should have almost recovered in the past half month. How could he have nosocomial pneumonia?"

"What are the results of the sputum culture?"

"MRSA! Haha, it's really a typical nosocomial infection."

"At least five hospitalized patients are infected? That's really serious."

"The ICU organized a hospital-wide discussion and has initially formulated a set of anti-infection treatment plans?"

"Thank God. Unfortunately, I am currently in isolation and cannot be of much help. I hope that by the time I return, my condition will be completely under control."

After hanging up the phone, Jian Lian Yun frowned, his face suddenly filled with sadness.

Wei Kang asked curiously: "What's wrong? From what you called just now, it sounds like you have hospital flu?"

Jian Jianyun immediately vomited her bitterness: "Yes, it seems that a girl was sent to a local hospital for infusion treatment by her parents because of a cold and cough. Later, not only did her condition not improve, but it also worsened."

"So he was sent to our hospital for treatment. He was not diagnosed with MRSA at first, but instead infected other patients in the ICU."

"Later, the condition never improved. I did a sputum culture and was diagnosed with MRSA. By this time, it was already too late."

"My patient stayed well in the ward, but his family members wandered around the hospital and brought germs from the ICU to the patient. Then he got pneumonia and was sent directly to the ICU. It was an unforeseen disaster."

"I was going to be discharged from the hospital soon, but what happened is that I am now lying in the ICU not knowing whether I will live or die."

"It is estimated that all the treatment costs will have to be paid by the hospital. Now I am worried that the patient will not be saved because he is over 60 years old, has underlying diseases, and just had surgery. His body is really weak and his immunity is completely weak."

"Except for that girl, several other patients were infected in our hospital. If they were not rescued, it would be a serious medical accident. There is really no way to explain it to their families."

"This is really difficult to handle." Wei Kang's face also became serious.

Nosocomial infections are infections acquired by patients in hospitals and are currently a headache for the medical community in various countries.

Because non-compliance with disinfection procedures, poor management and other man-made disasters are the main causes of most nosocomial infections, the industry regards this as a shame for the medical profession.

The cumulative incidence of nosocomial infections in foreign hospitals has remained at 4%, while the figure in domestic hospitals is about 8%. In any case, it is a relatively high number, and every occurrence will bring a lot of additional pain to the patient.

Nosocomial infections are mainly caused by some super bacteria that are resistant to common antibiotics. These super bacteria include Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus aureus (

MRSA), Acinetobacter baumannii, etc.

Among them, MRSA is the most famous. Pneumonia caused by this bacteria is often very serious. It will initially show flu symptoms, and then the patient will rapidly deteriorate until respiratory failure.

Data shows that the 48-hour survival rate of patients infected with MRSA is only 63%. If more than 50% of patients do not receive timely treatment, they will die within an average of 4 days after the onset of symptoms. It can be described as extremely vicious and very dangerous.

Wei Kang asked with concern: "How effective is the antibiotic program?"

Jian Jian Yun shook his head and sighed: "I don't know either. All I know now is that the patient is lying in the ICU, and his life or death is uncertain. There are three younger patients who may be able to survive, but it's hard to say for my patient."

"The plan the ICU used for the girl was intravenous infusion of vancomycin, but this antibiotic is very toxic to the kidneys. My patient may not be able to tolerate this adverse reaction, so I will consider using linezolid for treatment."

"But you know, these antibiotics have serious side effects. If used too much, they will cause harm to the body, but if you don't use other antibiotics, there is very little room for choice. Alas~"

Wei Kang couldn't help but feel a little worried when he saw her sighing.

Suddenly, something moved in his mind, and he remembered Sanqing's new project.

Nanopills are simply a solution tailor-made for this situation.

So, he immediately put forward constructive suggestions.

"Honey, actually, for the current situation in your hospital, Sanqing has a special nano-robot technology that may be used."

"This project has completed animal experiments, and the results are very significant. In the mouse model of acute Pseudomonas aeruginosa-infected pneumonia, nanopills significantly reduced the bacterial load and greatly reduced the animal's mortality."

"It also had extraordinary effects in the sepsis mouse model infected by Acinetobacter baumannii."

"More importantly, this new method uses only a very small amount of antibiotics during the entire treatment process, which can be said to pave the way for the development of nanorobots to treat bacterial infections in the human body."

Jian Jianyun's eyes widened in surprise and he exclaimed.

"Really? Wow, hubby, you are amazing, you can actually develop such a powerful thing."

"Just wait, I'll call Director Cui of the ICU right now," Jian Jianyun dialed the phone and asked, "How long will it take for this nano pill to be ready?"

Wei Kang mused: "The first clinical phase has been tried on healthy people and did not cause any adverse reactions. In the following clinical phase two trials, some patients will be recruited to try the drug."

"If I remember correctly, the company has prepared finished products for the common superbugs, just waiting to be used on patients."

"MRSA is the most common superbug. Even if it is made temporarily, it only takes 6-8 hours to mount the required antibiotic molecules on the nanoparticles."

"That's great." The worry on Jian Jian Yun's face disappeared, and he instantly became extremely excited.

Wei Kang also took out his mobile phone: "I will immediately ask the people in the nano laboratory to be ready to support the hospital at any time."

****

Kunming First People's Hospital.

Director Cui of the ICU was looking at the five patients in the ward, racking his brains to think of treatment plans.

Among them, a high school student named Xiaofang was the one who had been infected for the longest time. After 20 days of treatment, she has improved.

There are also two younger patients whose conditions have remained stable under antibiotic treatment and have not continued to worsen.

As for the remaining two patients, one has had chronic lung disease for more than ten years and has been in the hospital for a long time. His body has become resistant to many antibiotics.

Another man, who was in his 60s, had just undergone major surgery and his body's immunity was at its weakest when he was infected by the worst infection, a superbug.

Director Cui looked at the condition of these two people and was so helpless that he almost shed tears in an instant.

"Fortunately, these young patients have much better physical fitness and stronger immune systems, so they should be able to survive."

"It depends on the fate of the other two." He murmured to himself and slowly shook his head.

Lying on the hospital bed in front of him was a teenage girl. Her childish face showed a trace of pain, and she was obviously suffering from severe pain.

Xiaofang is a high school student in Kunming City. In the impression of most of her classmates, she is a girl who studies seriously and has good grades.

At the end of December, when the final exam was approaching, she stayed up several nights in a row to review and prepare for the exam.

As a result, my body immediately became exhausted. Not only was my body aching and weak, but I also developed fever.

At first, she thought she had just a common cold and that she would get better soon as long as she drank more water and rested.

As a result, after lying at home for two days over the weekend, not only did it not improve, but it got worse and worse. I coughed continuously and my body temperature once reached 40 degrees Celsius.

In this case, her parents were also anxious and took her to a hospital near her home for treatment.

After a series of infusions to reduce fever, my condition went up and down, but my cough never stopped.

Three days later, Xiaofang developed a high fever again, and a CT scan showed small patches of inflammation in her lungs, which meant that her lungs were obviously infected.

The doctor who treated her immediately arranged for her to be hospitalized for treatment.

Unexpectedly, less than half a day after being admitted to the hospital, Xiaofang's condition deteriorated rapidly, with symptoms of chest tightness and shortness of breath, oxygen saturation gradually declining, and even respiratory failure.

The doctor continued to increase her oxygen intake, but she still felt out of breath and her chest was so tight that she was almost suffocating.

My parents made a quick decision and transferred directly to the best tertiary hospital in Kunming, the First People's Hospital.

After arriving at the hospital for expert consultation, he was immediately transferred to ICU for treatment.

Various first aid measures were arranged immediately, including ventilator-assisted ventilation, lung CT review, sputum culture, blood culture and other specimen cultures, and none was left behind.

At first, the hospital did not think about nosocomial infection, but within a few days of assessing the condition and determining the treatment plan, patients in other beds in the ICU also developed similar symptoms.

At the same time, Xiaofang's condition continued to deteriorate. Not only was she on a ventilator, but she also continued to have a high fever. The partial pressure of oxygen in her body barely reached the standard. As for both lungs, almost all of them were consolidated, and the inflammation indicators were very high.

If the condition continues to worsen, I am afraid that I will need ECMO (extracorporeal membrane oxygenation machine), which is the so-called artificial lung.

In just one week, a healthy and lively young girl turned into a dying girl.

Director Cui of the ICU suddenly realized that Xiaofang's infection might not be an ordinary virus or bacteria.

At this time, the sputum culture results also came out. It turned out that she was infected with the super bacteria MRSA, and the blood culture also showed that Gram-positive cocci were cultured.

The ICU immediately organized a hospital-wide discussion and initially formulated an anti-infectious treatment plan for positive bacteria and hospital-acquired infections.

Fortunately, Xiaofang's drug sensitivity test showed that vancomycin is effective.

The ICU immediately gave her an intravenous drip of vancomycin and carried out all-round suppression of MRSA.

In the days that followed, Xiaofang's fever peak slowly and steadily dropped, and the support of the ventilator also slowly decreased.

However, other patients also broke out at this time.

A total of five patients were diagnosed with MRSA, and all were treated together.

Soon, the vicious nature of MRSA was exposed.

Complications followed one after another, including pneumothorax and massive airway bleeding, all of which started a crazy counterattack in the patient's body.

Soldiers came to stop them, and water came to cover them. In the rounds of MRSA battles, Xiaofang's condition gradually stabilized.

Her body temperature slowly returned to normal, and the ventilator's support gradually decreased to an offline level.

What is even more gratifying is that other important organs in her body were checked one by one, and no signs of MRSA infection were found. All infections were only concentrated in the lungs.

All this shows that Xiaofang is gradually recovering.
To be continued...