Chapter 509 The dawn of complete cure for diabetes

Eagle Country, Minnesota.

With the hot steam steaming from his head, Freeman lay in the jacuzzi with his eyes closed to relax, and the muscle fatigue all over his body was relieved.

As a professional athlete, he needs to perform high-intensity exercises every day to maintain his physical fitness.

After soaking for half an hour, he got up, wrapped himself in his bathrobe and returned to the living room.

At this time, the phone rang. After he answered the call, without saying a few words, his face suddenly became excited.

"What? You applied for the oral insulin trial qualification for me?"

"Great, I'll go there tomorrow morning."

After hanging up the phone, Freeman was immediately excited.

Just now, my personal doctor called and said that Sanqing Group's oral insulin has finally started clinical trials in Eagle Country. This new drug has outstanding efficacy and is easy to take, making it very suitable for athletes like him.

From now on, you only need to take oral tablets every day to achieve the effect of taking in insulin and controlling blood sugar.

If that doesn't work, at least he can take insulin orally without having to wear an insulin pump that looks like a pig's tail on his body.

Even if the breakthrough rapid application model is adopted, it will still take half a year to a year to verify the safety of the drug on a large scale.

It was replaced by a sense of social responsibility, which has become his life creed.

"Very good, several new drugs are progressing smoothly and have entered the third phase of clinical trials."

When that day comes, the treatment of diabetes will undergo tremendous changes, and every patient will benefit from it.

Sanqing currently has the technology to differentiate stem cells into artificial blood and has made a breakthrough in stem cell research.

Wei Kang had already planned for this, and completely curing diabetes was his ultimate goal.

Unfortunately, phase III clinical trials require a large number of samples and long-term clinical observation, and cannot be quickly put on the market in a short time.

Especially for chronic disease drugs that need to be taken for a long time, the patient's life is not in danger for the time being. There are also similar drugs on the market, with more stringent requirements and a longer time.

The maintenance time is also very limited. All patients who undergo cell transplantation will develop immune rejection after a few months, or at most one to two years, and return to the state before transplantation. The effect cannot be maintained permanently.

As more and more drugs were developed, he felt the burden on his shoulders became heavier and heavier.

That was the first time he heard about this disease. When the doctor suggested that he end his skiing career and change his job, it was like a bolt from the blue, which made him extremely depressed.

However, if the pancreatic islet cells are damaged, even if blood sugar is well controlled, life-long medication or even insulin injections may be required.

And it will not be considered a complete success until it is listed on the market and sells well.

No longer do you have to endure the sudden alarm sound of the insulin pump, no longer have to keep an eye on the speed of the insulin pump, and worry about the insulin infusion being interrupted.

"Eagle Country is indeed a free country. No matter how bloody things are, things can happen. Fortunately, the final result is not bad."

As a technology-driven pharmaceutical group, the choice of research and development direction must naturally fit with its own technical field. It cannot be like investors who flock to any hot track they see.

This thing probably won't last long.

So, now that Sanqing is at his current level, as the light of human medicine, he has become the tallest person and the one at the front.

Only the pharmaceutical industry is still in a stagnant state with no improvement, not even a single original drug that is selling well around the world.

Before the rise of the Sanqing Dynasty, Chinese giants were present in many industries, and they were among the best in the world.

The long-term solution is to first consolidate the basic foundation of type I diabetes, and then combine its own advantages to develop deeply in this field.

The reason why diabetes cannot be cured is closely related to the damage of pancreatic islet cells, insulin resistance, and insulin secretion.

"The next step is to proceed step by step. When the third phase clinical trial is completed, it will be launched next year at the earliest."

However, there are currently many obstacles to using stem cell technology to reconstruct islet function, and the technology for extracting and isolating islet stem cells and inducing the maturation of insulin-secreting cells needs to be further improved.

After doing this, he started to check the progress of other projects.

Such a complete set of clinical trials costs extremely high amounts of money, often tens of millions of dollars. Except for pharmaceutical giants, few pharmaceutical companies can afford it.

No more having to stick an insulin pump on your belly.

Sanqing is responsible to the motherland, to society, and even more to the millions of patients.

"The road is long and long, and I will search high and low. How difficult it is to truly cure a disease."

If you want to wear a crown, you must bear its weight.

If you are number one in an industry and cannot be aggressive and pioneering, then what vitality does this industry have?

In the past, Huaxia Pharmaceutical Industry was just waiting to die, desperately fighting internal conflicts, and fighting to the death for the sake of a generic drug market.

"The pattern of the insulin market has been established. At least overseas, oral insulin will occupy the mid-to-high-end market. The price of injected insulin has dropped significantly, making it a daily drug that even the poor can afford. This is a great benefit for people with diabetes."

There is a lack of a universally recognized method for fully differentiating stem cells into islet cells.

The next day, he went to the scheduled medical institution and started trying the medicine.

If we say that at the beginning, he was just the boss of a small pharmaceutical company, and he just wanted to develop a flagship drug that was like a cash cow, so that he would not have to worry about money in this life.

"If the three giants can complete the transformation and focus on anti-diabetic drugs, it is hard to say whether it will be a blessing or a curse."

This gave Wei Kang enough confidence. He believed that as long as he conducted in-depth research in this area, sooner or later he could differentiate pluripotent stem cells into islet cells and produce islet cells for clinical use just like blood.

Wei Kang sighed and said: "We, the medical people, can only burn our lives and devote ourselves to it regardless of our own safety."

Not to mention people with type I diabetes. Most of the pancreatic islet cells have been damaged as soon as the disease occurs, and they can only inject insulin throughout their lives to maintain life.

Just like a bird regaining its wings and flying high in the sky, he once again experienced the feeling of freedom.

People saw his achievements and praised him full of praise, but no one knew that he had to test his blood sugar five or six times a day, inject insulin every day, and wear an insulin pump 24 hours a day.

Even when the sky falls, there are still tall people who are holding on. They are overcoming obstacles in the technical field, and there are scientists who are at the forefront.

If many people with type II diabetes only have problems with insulin resistance and secretion, they can still recover by taking medicine and diet control.

Pancreatic islet cells are highly differentiated cells that cannot replicate themselves. Once damaged, they cannot regenerate and cannot secrete insulin normally.

Diabetes itself is a complex chronic disease, and new treatment ideas and solutions are emerging in an endless stream. As long as they are effective, they will sell well.

If you can't beat them, then give up, change the track to work harder, and never hang yourself from a tree. This is the fine tradition of these old pharmaceutical giants.

Islet Stem Cell Transplantation Project

Then start assigning project personnel.

The human body's pluripotent stem cells can differentiate into islet cells. As long as these differentiated cells are extracted, cultured in vitro islet cells, and transplanted into the human body, insulin can be secreted normally and diabetes can be completely cured.

In some studies, pancreatic islet stem cells transformed from embryonic stem cells transformed into fetal tumors when treating diabetic mice, resulting in the loss of hypoglycemic effect and causing great safety issues.

*******

Just as the reputation of oral insulin was slowly fermenting across the ocean.

Wei Kang knew very well that Eli Lilly's reason for lowering prices was naturally on its GLP-1 antidiabetic drug.

There are many people like Freeman who are involved in drug trials.

This oral insulin is really as easy to use as he imagined.

Wei Kang sighed, calmed down, clicked on the computer and created a new project folder.

In fact, islet cell transplantation has always been a cutting-edge topic in medicine.

Through a series of strict measures, he finally successfully controlled his condition, maintained a high level of competitive physical fitness, and completed a reversal of fortune.

Some other tissue cells, such as liver cells, have a low degree of differentiation, can continue to replicate, and have strong regenerative capabilities.

"At least Eli Lilly was the first to give in, and the price of insulin has been significantly reduced. The burden on diabetics can finally be greatly reduced, and they can live a better life."

Domestic clinical phase III trials are also progressing simultaneously.

"There's no rush for this, you can take your time."

Wei Kang is very satisfied with the progress of this project.

No, the effect is even better.

As of today, he has won multiple gold medals as a diabetic athlete and is well-known around the world.

These problems are not too big for Wei Kang.

Even after it is launched on the market, it must continue to follow up on Phase IV clinical verification. If there are any problems, it may be ordered to be delisted at any time.

But in the final analysis, it is still a problem of damaged islet cells.

Freeman has never been more confident about this than he is today.

When the trial ended, everyone felt disappointed and couldn't accept it. They wished they could buy this new drug in the pharmacy right away.

Sanqing currently has some hypoglycemic drugs, but they are only in one or two directions and are not the most popular categories.

This is why the successful development of a new drug is only the first step, and reaching the third clinical phase is half the success.

Having this thing with you all the time is too inconvenient for high-intensity exercise.

Diabetes, a disease of modern affluence caused by the abundance of food, also has hope of being completely cured.

Even hereditary diabetes is caused by multiple gene mutations and is not inherited from a single gene. What is inherited is not the disease itself, but the susceptibility to diabetes. Certain environmental factors must contribute to the occurrence of diabetes.
To be continued...