Chapter 511 The blood vessels disappeared?

"Xue Bo...well, something happened to that lab mouse."

At the door of the office, an intern stood there and said tremblingly. After speaking, he quickly lowered his head, not daring to meet his eyes.

Xue Shen raised his head from the computer and recognized the intern, who seemed to be looking after laboratory mice, and suddenly looked confused.

"Something happened, what happened?"

The first thought was that the mouse had an adverse reaction. Did it die suddenly?

When I looked back, I thought it was impossible. I just transplanted a small section of the femoral artery into the mouse. What could happen?

The intern rolled his eyes and hesitated: "It seems that the transplanted blood vessel is missing."

With a "bang" sound, Xue Shen slapped the case and stood up.

"Explain to me clearly what blood vessels are missing."

He leaned forward, his eyes as terrifying as an eagle's, staring at the intern with all his might.

The operation was very successful, there was little bleeding during the whole process, and the mouse was in very good condition after the operation.

The first round of mouse experiments has proven the effectiveness of the artificial blood vessel, and it will be sent to a third-party animal experiment center next week for the second round of pig thoracic aorta replacement surgery experiments.

"The graft was well connected to the aorta in the body, without any infection, and no vascular necrosis or tearing was seen at the vascular ligation and anastomosis site."

As time goes by, the artificial blood vessels are completely integrated into the body and will become exactly the same as natural blood vessels in appearance, behavior, and function.

What can we do? One month has not come yet, the experiment has not been completed, and the samples are gone.

Xue Shen put on gloves, caught a mouse from the cage, and looked at the surgical wound carefully.

He has done corresponding market research and is well aware of the products of his friends, but he does not pay attention to domestic products at all.

Then we received the biggest surprise in our life.

During this time, all the sows have been put out of the slaughterhouse. Since they are fed better ingredients, the meat is very delicious and it has become very popular after being launched in the canteen.

"Haha, what the hell are those artificial blood vessels commonly used on the market?"

"Husband, do you think so?"

"It's impossible to disappear into thin air."

"The number of endothelial cells on the intima surface in the middle part of the artificial blood vessel is significantly less than that at the edge, and a large amount of fiber components can be seen, and the test showed that the components are collagen fibers."

Even among high-value consumables, artificial blood vessels are among the most high-end. Domestic ones are really not good at this, and the problem of preventing bleeding has not been solved for a long time.

Artificial blood vessels can be said to be the ultimate interpretation of the need, need, and need. It belongs to system engineering and is an interdisciplinary subject, involving materials engineering, bioengineering, medicine and textile engineering. It requires the input of talents from various disciplines, and it also requires breakthroughs between industries.

Only when there is a gap can success be achieved.

"No, we need to dissect it in advance to see what's going on with the transplanted blood vessels."

In terms of high-end expanded polytetrafluoroethylene materials, there is a big gap between upstream and foreign countries. Not to mention artificial blood vessels, even supporting medical sutures and cardiac patches, there are no large-scale industrialized products in China.

It also relies on imports and is very expensive.

"What about my artificial blood vessel that was so long and thick? It really disappeared." Xue Shen was dumbfounded.

"Okay, let's look at large animal experiments next."

Because the level of the domestic polymer material industry itself is average, most of the polytetrafluoroethylene materials produced are general-purpose products with low quality and are mid- to low-end products.

"Endothelial cell growth can be seen on the inner surface of the artificial blood vessel lumen. Among them, the endothelial cells of the artificial blood vessel near the anastomosis are growing well, showing a typical uniform paving stone-like change, with the long axis parallel to the direction of blood flow."

It took me a while to jump up, and I was so excited that I couldn't stop walking around.

In this way, he can be guaranteed to enjoy organic meat from the farm for breakfast, lunch and dinner.

The medical student coughed lightly and explained the anatomy results and the slice observation results under the electron microscope.

When it grows together with the new tissue and blood vessels, it becomes just like the original blood vessels, and it is difficult to distinguish them under the layers of muscles.

"Imported goods are nothing more than that. As for other domestic goods, they are even more shoddy and cannot stand up at all."

When the artificial blood vessel is first transplanted, it has a certain hardness and unevenness, and the foreign body feeling can be easily felt under the wound.

The two ends have grown together with the mouse blood vessels, and the sutures have been absorbed. The entire femoral artery is almost the same as the original one, and no difference can be seen at all.

"As for the natural mulberry silk artificial blood vessels, they are just a gimmick. No matter how small the caliber is, it does not matter as small as 1 mm. Not to mention the low strength, even if the transplant is successful, it will be sutured and it will naturally degrade in a few months.

The bamboo basket is nothing, and it’s hard to say whether the degraded particles are safe in the human body.”

"The mice were not given any anticoagulant or antiplatelet drugs after surgery, which proves that the artificial blood vessels have high patency and good anti-thrombosis ability."

After a while, he finally made up his mind and stuffed the mouse back into the cage.

At this point, Sanqing's canteen has become completely famous.

"I've been so busy these past few days that I realized I hadn't been there. I went to the bathroom at noon and saw this pregnancy test stick in my bag, so I thought I'd just use it."

"HE staining under the microscope shows that the artificial blood vessel is completely covered and surrounded by autologous tissue, and the two ends naturally migrate to the intima of the normal artery, and the tissue structure from the inside to the outside is basically the same."

It even became popular on hot searches and became a symbol of weird and delicious food, driving the tourism business of Sanqingyuan.

Xue Shen shook his head before he figured out what was going on.

"Overall, various data and test results show that this is a very ideal artificial blood vessel product."

He was still shouting things like "Great, finally it's done."

Xue Shen clenched his fists and waved them excitedly in front of him. It took him a while to calm down.

No wonder the intern said he couldn't feel the artificial blood vessel.

Wei Kang stared blankly at his wife who flew into his arms as soon as he walked in. He was completely stunned.

Among them, aortic disease accounts for the largest proportion, accounting for approximately 62%.

Because after long-term hemodialysis, most patients' commonly used blood vessels will harden and shrink, and their conditions will worsen day by day, so they have to take this last resort to maintain their lives.

"Everyone, keep up the good work and come on!"

My whole body felt light and airy, as if I had dreamed of returning to space, and even the air I breathed had the scent of candy.

The intern suddenly shivered like a little chicken and almost cried.

"The polytetrafluoroethylene material has good anti-thrombotic properties, but its texture is as hard as the skin of an 80-year-old grandmother's feet. If it is used for surgical suturing, it will be a huge challenge for doctors, not to mention 30% of blood vessels are unblocked.

If you have sex, you are a piece of useless wood."

There is no doubt that after witnessing the miracle of artificial blood vessels with his own eyes, he has great confidence in his own products.

Even the Devil's Muscle Pig was sold out and became a delicious pork chop rice dish in the cafeteria.

The mouse howled miserably when he touched it, and even the surviving mice in the cage looked at him with horrified eyes before reluctantly stopping.

He directly asked the interns to take care of them. If nothing happened, they would all be executed in a month. The transplanted blood vessels would be removed for pathological anatomy and the data would be compiled into a perfect experimental report.

Soon, an artificial blood vessel about 3 centimeters long and an autologous aorta of 0.5 centimeters at each end were completely removed.

"Xue Bo, it's not my fault. I observe the mice every day. It was very obvious at first, and I could even touch the transplanted blood vessels. After the wound has healed in the past few days, I can no longer feel it."

Xue Shen muttered in his heart and came to the laboratory.

Netizens across the country now know that there is a small stall here that often sells some weird genetically modified foods.

There are 40,000 to 50,000 patients in China who are going to the hospital to undergo surgical aortic treatment every year. Most of these patients need artificial blood vessels to replace the diseased blood vessels.

Still unwilling to give up, he touched and pinched the mouse again and again.

This kind of pork chop is full of strong lean meat, has a special flavor, and is limited to the season. It set off a craze in the canteen that day, attracting countless diners who are looking for novelty.

"Hahaha, great. This is a good thing." After Xue Shen figured it out, he was instantly overjoyed.

Of course, he always orders takeout and has the security deliver it.

"This..." Xue Shen opened his mouth wide and was speechless for a moment.

The two sat hugging each other, Wei Kang still couldn't restrain his joy, caressing his wife's abdomen with his hands, smiling from ear to ear.

Xue Shen breathed a sigh of relief: "This doesn't mean anything, maybe it's blocked by the muscle layer..."

The intern is not a professional doctor, so it is normal for him to not be able to touch it.

The two main application areas are aortic disease in cardiac surgery and hemodialysis.

But if there are artificial blood vessels that are the same as natural blood vessels, they will no longer need to perform endovascular fistula surgery, but only need to perform artificial blood vessel transplantation.

As soon as I entered, I saw several snow-white and tender mice lying in the cage. They were all full of energy, squeaking and exchanging post-operative care experiences.

"Hehe, as expected, you can't keep thinking about this kind of thing. The ancients are right, flowers planted with intention will not bloom, but willows planted with no intention will form shade."

"After the specimen was taken out and incised, the inner surface of the blood vessel cavity was completely covered with a white membrane, and no thrombosis was seen."

****

Just when the artificial blood vessel project was going smoothly.

"What? Are you pregnant?"

I found that white hair had grown on it and it was almost healed, leaving no trace.
To be continued...