Chapter 531 Tissue Engineering, On the Feasibility of Artificial Bladder(2/2)
Xue Shen said thoughtfully: "When you say that, I understand that it is indeed very difficult."
He immediately laughed: "Now that we know where the difficulties are, it's good. At least we have a goal to work towards, right? As long as we keep working hard in the direction, these difficulties will be solved sooner or later."
"Bah bang bang!" Ding Mian clapped his hands and praised loudly: "Yes, your attitude is exactly the spirit of our generation of scientific researchers. I can tell at a glance that I have found the wrong person this time."
He touched his forehead and said with some embarrassment: "By the way, I seem to have not had time to say that my new project is the artificial bladder project."
"Artificial bladder?" Xue Shen was surprised, and then became excited: "So this is what you were talking about at the beginning. This is a hollow non-tubular structure, and it is also very difficult. Are you sure?"
Ding Mian nodded, shook his head and said, "It's hard to say, I only have a rough idea."
"Tell me about it?" Xue Shen stretched out his hand again.
Ding Mian adjusted his glasses and talked eloquently.
"There have been clinical cases of artificial bladder cultivation and transplantation abroad, but it has not yet become popular, and there is no precedent in China. For patients who need bladder removal, the common surgical plan is to intercept a section of the large intestine and then transform it into a bladder.
Then sew the ureter back on."
"This has many clinical limitations. Some patients' intestinal tracts are not healthy and cannot be intercepted. Long-term use of another patient will also cause some problems."
"Artificial bladder transplantation technology can perfectly solve the patient's problems. It does not require autologous materials and has no restrictions on the patient's physical condition."
"This new bladder is imitated from a real bladder and consists of three layers of material. The outer layer is muscle, the inner layer is bladder epithelium, and the middle layer is tissue protein collagen that plays a connecting role. It needs to have a certain degree of elasticity. The entire structure looks
It looks very much like a baked layer cake.”
"I just told you that it is not difficult to obtain and culture cells. Just take some living cell samples from the patient's bladder and culture the muscle cells and bladder epithelial cells separately."
"After the cells are cultured, they will be placed on a bladder-shaped degradable biological scaffold. Once the entire new bladder is cultured, it will be transplanted into the patient's body."
"Since the bladder is a very small and hollow mass when it contracts, it does not require many cells, so it is a relatively easy choice."
"If all goes well, within a month at most, the artificial bladder will be able to work like a normal bladder in the patient's body. In a few months, the degradable stent will be decomposed, and blood vessels and nerves will grow on the artificial bladder to connect with surrounding tissues. stand up."
"During the whole process, the techniques for transplantation surgery and cell culture are very mature, and I can do it."
"The only difficulty lies in the biological scaffold, but after the successful research on artificial blood vessels, it has been solved."
"I have seen the performance parameters of artificial blood vessels. The elastic protein used in it is very suitable for artificial bladders. It can provide elasticity several times higher than that of normal bladders, so it can better control urination and significantly improve the patient's urinary incontinence symptoms. "
"This biomaterial only needs some improvements to make it perfectly suitable for the artificial bladder project."
"What do you think?" Ding Mian extended his hand enthusiastically and said expectantly: "Would you like to do it together?"
Xue Shen suddenly smiled, held the other person's hand tightly, and said firmly.
"No problem, Ding Bo, I'm going to fly with you this time."
Chapter completed!