Chapter 561 Clinical Artificial Bladder, Soul Torture

Author: Riding a pig to dig a hole

Chapter 561 Clinical Artificial Bladder, Soul Torture

Sanqing Headquarters, Stem Cell Laboratory.

A whole wall of cages were filled with experimental animals of all sizes, most of which were rats and mice, and some were white rabbits with red eyes. The bottom floor contained several small pigs and

macaque.

Ding Mian and Xue Shen stood in front of the cage, with their hands in their pockets and their eyes unblinking. They looked like two pillars, and they always maintained this posture without moving.

There were three cages in front of the two of them, with two rabbits in each. They were carelessly munching on the carrots they were fed.

A few more minutes passed, and Xue Shen finally couldn't bear it any longer: "You wouldn't pull me over just to watch a rabbit eat carrots, would you?"

Ding Mian said without looking back: "It's very beautiful, don't you think? And rabbits that have undergone transplantation are completely different from rabbits that have not."

He pointed to the four cages: "The rabbit in cage No. 1 had its bladder removed, the animal's own cells were used to inoculate the scaffold, and then an artificial bladder was implanted again. The rabbit in cage No. 2 had its large intestine cut off and transformed into a bladder, and then the ureter was sutured.

"

"No. 3 was the healthy group. They had a sham laparotomy, which meant making an incision, doing nothing, and then suturing again."

Xue Shen looked at it carefully a few more times, shook his head blankly and said, "I can't see any difference."

Then he became impatient: "What on earth are we waiting for?"

"Wait for the rabbit to pee." Ding Mian replied simply.

"Huh?" Xue Shen was dumbfounded for a moment and blurted out: "Are you kidding me?"

Ding Mian glanced at him and laughed loudly: "I'm kidding you, I've observed this rabbit eight hundred times."

"The rabbit's artificial bladder technology is relatively mature. As for using patients' bladder tissue to cultivate artificial bladders, the related technology is not news in clinical practice."

"I brought you here this time to see the artificial bladder."

Xue Shen was immediately overjoyed: "Great, let me tell you, you took the biological scaffold and said you wanted to plant cells on it, but there is no response. You are waiting for me here. Take me there quickly."

The two people put on isolation suits, disinfected and sterilized, and then came to another laboratory.

As soon as he entered, Xue Shen was shocked by the scene in front of him.

I saw a transparent glass cabinet placed on the workbench in the middle, filled with cell culture fluid.

A meat sac the size of a table tennis ball is suspended in a transparent culture medium, with a 1 cm thick tube connected to each end.

The tube on the left is connected to a closed box, and the tube on the right flows into a plastic bucket, which already contains some light red liquid.

Xue Shen stepped forward quickly, put his face in front of the glass cabinet, and asked in shock: "Is this the artificial bladder you cultivated?"

"That's right."

"What about other things? What are these tubes used for? Is there urine in them? Why is the liquid in the bucket red?"

Xue Shen's questions were like a barrage of questions, one after another without any pause.

Ding Mian said proudly: "Don't worry, come one by one and listen to me explain in detail."

"In fact, this is not just an artificial bladder, but an entire urinary system."

"What, you've done the entire urinary system? What about the kidneys? Where are the kidneys?"

Xue Shen interrupted Ding Mian's story with an exclamation. He asked eagerly while looking around, looking for the imaginary artificial kidney.

"This..." Ding Mian paused for three seconds, pointed to the closed box next to him, and said, "Actually, this isn't an artificial kidney, it's just a blood filter and bioreactor."

"Anyway, please listen to me first." He clapped his hands to calm the excited Xue Shen before continuing.

"This artificial urinary system is actually quite simple. It mainly consists of three parts: the so-called 'artificial kidney' and artificial bladder, as well as the ureter and urethra."

"You should be familiar with artificial bladder technology after we have been working together for so long, so I won't say more."

"Both the ureters and urethra use technology similar to artificial blood vessels. This technology is not high, so I won't bother to go into details."

"As for the artificial kidney, it is divided into two parts. The blood filter is similar to the current hemodialysis technology. It uses a nanoscale biological filtration membrane, which is similar to the glomerulus and can prevent large molecules from passing through.

At the same time, small molecules are allowed to pass."

"The other part of the bioreactor is mainly responsible for the reabsorption of urine in order to reduce the amount of urine to close to the daily urine amount of a normal person, which is about 1.7 liters."

"The filtration mechanism of the entire setup mimics the native kidney. Since the glomerular cells are a capillary network surrounded by the glomerular capsule, when the blood flows through these capillary networks, the blood will be significantly higher than the normal level, thus making the blood

The substances in it will filter into raw urine."

"This blood pressure difference is a normal physiological phenomenon and can be used as a power source for hemofiltration, which is very useful."

"The original urine in the human body is originally absorbed by the glomerulus for a second time. This is repeated, and finally it is excreted as urine."

"The bioreactor also imitated this part of the function, but due to my lack of technology, the effect needs to be improved, so the secondary absorption of the original urine was not very complete, and the final urine contained a little blood and appeared light red."

Ding Mian scratched his head and said with some embarrassment.

"But don't worry, the artificial bladder is still very useful. I'll show you the effect."

As he spoke, he operated on the control device next to him and heard a buzzing sound. A stream of light red liquid spurted out from the ureter and flowed into the artificial bladder.

The flesh sac instantly expanded like an inflated ball.

All of a sudden, it changed from a table tennis ball to an apple.

Then it gradually expanded to the size of a grapefruit.

"This..." Xue Shen was stunned again: "This, are our human bladders that big? How much water did you put in?"

"About one liter of water, plus what's already in it, it's probably a little more than one liter." Ding Mian said nonchalantly: "Look, it's time to urinate."

"What?" Before Xue Shen could react, he saw the flesh sac slowly deflating, and the liquid inside flowed into the plastic bucket at the other end along the urethral tube.

The sound of gurgling water echoed in the laboratory, and it took a while for it to stop.

"This, the sound is really similar." Xue Shen sighed in shock.

"No, how did you make it urinate? Doesn't it cause urinary retention?" Soon, he keenly discovered the key.

"Hey, it will automatically pee when it is full." Ding Mian picked up the plastic bucket, returned to the "artificial kidney", and poured the entire bucket of bloody urine into it again.

"Okay, if you filter it a few more times, it will turn into yellow urine."

After doing all this, he walked up to Xue Shen and said seriously.

"The only problem now is that the artificial bladder grown in the laboratory has no nerve connections and cannot control urination, holding in urine and other behaviors. If you want to completely discharge it, you can only fill it up and let it discharge automatically. Otherwise, the urine will remain in the

in."

"However, rabbit experiments have confirmed that neural connections will be restored after transplantation of artificial bladders, so it should be similar in humans."

Xue Shen said thoughtfully: "Well, that means artificial bladder can only go so far in the laboratory. Then it must go to clinical practice to get the most realistic results."

He suddenly remembered something and asked again: "What about blood vessels? Can blood vessels be regenerated?"

Ding Mian chuckled: "Well, blood vessels, small case, these cultured cells contain small signaling proteins that promote blood vessel growth, that is, cell growth factors. When implanted into the patient's body, they can grow blood vessels while avoiding cell apoptosis.

Death."

Xue Kun nodded, his eyes instantly shining: "Then what are you waiting for? Hurry up and apply for clinical practice."

"Hehe, didn't I ask you to take a look first and then report to the General Wei?" Ding Mian grinned: "Which of us brothers is following the other? You also have a great contribution to this project."

"You kid, get on the road!" Xue Shen patted the other party's shoulder excitedly, feeling deeply moved in his heart.

In fact, he also understood that Ding Mian had been working hard on this project from beginning to end. He only provided part of the biological scaffold, but actually did not contribute much.

If this was the case in the laboratory where I worked before, the credit would definitely not fall on me. If someone went too far, my name would not be mentioned, and there would be no way to tell the difference.

Unexpectedly, Ding Mian was so conscientious that he directly took himself to report to his boss to ask for credit.

Sure enough, the working atmosphere of Sanqing is indeed unique. There are no complicated KPIs and there is no huge pressure for final elimination. The relationship between colleagues is naturally extremely harmonious, and there is not so much intrigue and competition for fame and fortune.

Here, everything depends on performance. Your superiors will always only look at what you have accomplished and what problems you have solved, rather than how beautifully you made your ppt or how flawlessly your report was written.

In this way, everyone naturally only has projects in mind and is willing to collaborate and work together for a common goal.

Everyone has their own role in the project, and as long as they contribute, they will not be forgotten.

The relationship between people has returned to its origin. Everyone gets along with each other in a simple and friendly way.

It felt to him like he had returned to his school days, where everyone was in the same river, competing healthily and moving forward courageously, instead of being at odds with each other, trying to get together and hold each other back.

Thinking of this, a warm current surged into his heart. Xue Shen's sense of belonging to Sanqing had never been so strong.

****

“Can artificial bladder apply for clinical trials?”

When Wei Kang saw the news, he couldn't help but feel a sense of surprise.

The artificial bladder project was completely a spontaneous research project conducted by his subordinates and was not arranged by him.

The results are now available, which is enough to prove Sanqing’s self-research capabilities and its potential in the field of stem cell regeneration.

Coupled with other clinical projects, Sanqing’s current R&D accumulation is bottomless.
To be continued...