Chapter 481 Sharp pharmaceutical giant
The doctors in the audience couldn't believe their ears.
The clinical treatment of gastric disease has always been a headache for gastroenterologists in the 1980s. It’s okay in China. There are some classic traditional Chinese medicine prescriptions that nourish the stomach and can relieve it in some ways.
In the West, doctors know that stomach pain is directly related to excessive secretion of gastric acid, but they have never found a good treatment. At most, they can use some alkaline drugs to neutralize it.
In Chinese dialect, this treatment is "treatment of symptoms but not root cause". Today, if the pain is painful, take some medicine, stop it if it is not painful, continue to take it, and repeat it over and over again, and never break the root.
Even ordinary alkaline neutralizing drugs are not very effective, especially for gastric ulcers, where there is no particularly good way.
Anyone who has had stomach problems or gastrointestinal ulcers knows that it will make the whole body feel uncomfortable if you have stomach pain.
Ordinary ones are sour water coming out at a mouthful, while more serious ones are radiating pain in the back. This burning pain is like a fire catching at the position under the xiphoid process.
Long-term, periodic, seasonal burning pain, and eating can induce or aggravate it is one of the characteristics of stomach pain.
Don’t underestimate stomach pain or excessive gastric acid secretion for a long time, because the stomach is in an "inflammatory" state for a long time, and the tissue cells will begin to degeneratively.
Isn’t there a saying: “It starts with inflammation and ends with cancer.”
So when Chen Chun said that their radical cure rate against Helicobacter pylori reached 80%, everyone could not believe their ears.
What does this mean? It means that 90 of the 100 patients with stomach disease have a clear history of Helicobacter pylori infection, and 72 of these 90 people can be cured and say goodbye to stomach disease from now on.
Before this, the mainstream medical community made it impossible to cure stomach problems and could only be treated symptomatically.
Now the Chinese doctor suddenly announced that they have mastered a treatment method that can cure most stomach problems. Can you not be amazed?
After all, if the Chinese doctor's view is valid and the paper confirms it, then all the digestive system textbooks around the world will have to be rewritten.
Jiro Ianda from the Affiliated Hospital of the University of Tokyo Medical School stood up, took the microphone and asked:
"Doctor Chen Chun, what is the treatment principle of your quadruple therapy? In addition, I have never heard of proton pump inhibitors."
Chen Chun replied with a smile: "I can answer you in the first question, and I think I should ask Dr. Zheng Haisheng, the inventor of the proton pump inhibitor, to answer the second question."
Professor Gregory smiled and said, "Dr. Zheng is also a young doctor. Wow, Dr. Hua is really shocking. This makes me feel that I am too old?"
A burst of laughter rang out in the venue.
Zheng Haisheng stood up from the seat with a blushing face, and he seemed much more nervous. Chen Xia shouted from the side: "Come on, brother-in-law, don't be looked down upon by Chen Chun, you want to bring glory to our men."
"Okay, I'll tell your sister, you said that to her."
After saying that, Zheng Haisheng also walked onto the podium and sat next to Chen Chun. Seeing that there were crowds of people on the stage, he swallowed nervously again.
Chen Chun has already started answering the first question:
"Our research has found that Helicobacter pylori is a spiral, microanaerobic bacteria with very strict growth conditions. The first principle of treatment is the application of antibacterial drugs.
According to our multiple drug sensitivity experiments, several antibacterial drugs such as amoxicillin, clarithromycin, furazolidone, metronidazole, tetracycline, etc. are the most effective. According to our many clinical experiments, the best way to form is amoxicillin + clarithromycin combination.
The second treatment principle is to inhibit the secretion of gastric acid. The best medicine now is H2 receptor blocker. However, Xiangjiang Pumpkin Vine Pharmaceutical Company has experiments showing that another drug has a much better acid inhibitory effect than H2 receptor blocker. They named it proton pump inhibitor. Please ask Dr. Zheng to introduce it to you later.
Bismuth agent is a mucosal protective agent. It mainly acts by inhibiting proteases, urokinases and phospholipases produced by Hp, thereby inhibiting Helicobacter pylori.
These four types of drugs kill Helicobacter pylori in all aspects through this mutual cooperation. Of course, we must also be alert to the possibility of recurrence. This is another topic, the transmission pathways of Helicobacter pylori and how to prevent it."
Chen Chun just put down the microphone, and the applause was much warmer than just now. After all, the treatment plan was not obtained through speculation. It was completely reasonable and well-founded. If there was research, experiment and clinical comparison, the credibility would be higher.
Zheng Haisheng picked up the microphone at this time and stuttered a little: "I, I'll answer the second question."
Chen Chun suddenly kicked him gently.
This warning from my wife is obviously very effective. Zheng Haisheng had good psychological qualities, but he calmed down instantly and coughed a few times to continue answering the question.
"I was also commissioned by Xiangjiang Pumpkin Vine Pharmaceutical Company, so I carried out the research and development of this drug. Regarding the pharmacological effects, this is the case.
The secretion of acid by gastric wall cells is through H and K-ATP enzymes on the membrane, and the H-ATP enzymes are exchanged for H-K. After the drug is absorbed into the blood, it diffuses into the cells of the human gastric wall, and binds covalently with H-K-ATP enzymes, irreversibly inactivates the pump molecules.
Gastric acid secretion only starts again when new pump molecules are synthesized and inserted into the cell membrane. Therefore, this type of drug inhibits gastric acid and lasting effects, and can reduce the secretion of pepsin.
This type of drugs acts on the last link of gastric acid secretion. Therefore, regardless of whether there are other factors that stimulate gastric acid secretion, this type of drugs can effectively inhibit the secretion of gastric acid..."
When Chen Chun and Zheng Haisheng said the names of "Xiangjiang Pumpkin Vine Pharmaceutical Company" respectively, the doctors present were fine, but the representatives of the pharmaceutical companies below the audience keenly remembered the name of the company.
According to international practice, if the research on this topic is entrusted by a certain pharmaceutical company, then all the system drug patents generated should be in the hands of the entrusted company.
If this "quadruple therapy" is proven to be reliable and effective, then the patents of these drugs will be valuable. You should know that this is a super market of tens of billions of dollars, or even tens of billions of dollars in the future.
The US dollar was still very valuable in the 1980s, and 10 billion US dollars was a very amazing and huge data, enough for these international pharmaceutical giants to go crazy.
This patent, which came out of a gap in the Xiangjiang Pharmaceutical Company, will soon become a golden cake that major pharmaceutical companies compete for.
Chapter completed!