In the laboratory, Yang Rui touched his head and wrote a note on paper, considering the next experimental goal. He seemed to be idle, but his brain was actually running violently.

On the contrary, Huang Mao and others worked diligently in front of the test bench and were busy re-verifying the data to complete the minor revision of the paper.

The dynamic relationship between the experimental dog and the researcher is almost exactly the same as that of the people and dogs who throw Frisbee in the park to walk their dogs.

If the cynical experimental dog sees this familiar scene, it will definitely talk about the issue of laboratory exploitation.

However, this is how normal laboratories work.

And the higher the laboratories are, the less meaningful the simple labor and hard work are.

As the head of the laboratory, Yang Rui's work in the laboratory is mainly about raising questions.

The question mentioned here is actually to put forward your own hypotheses or ideas based on the current scientific research achievements, especially the hot topics at the forefront of science.

For example, in the study of potassium channels, Yang Rui proposed the hypothesis that by cloning mutant genes, the structure and properties of ion channels can be verified.

This can be said to be a very difficult and breadth hypothesis. In order to achieve it, Yang Rui proposed a second layer of assumption: we can direct mutagenesis of the genes we want to mutate.

Similarly, in the second layer of concept, Yang Rui has further detailed concepts, such as directional mutagenesis organisms, which are suitable for fruit flies.

This step-by-step idea and hypothesis seems easy but is actually difficult, and it is also the primary condition for whether it can become the head of the laboratory.

The work of Huang Mao and others is actually to solve problems and complete Yang Rui's ideas and assumptions.

In order to complete their work, Huang Mao and others also have to put forward their own assumptions, which is also a self-training for them. The better the researcher, the faster he can become independent.

As for natural science, ideas and hypotheses must be based on a solid foundation, that is, the preliminary research results have been obtained.

Of course, how solid and how much it is, it actually depends on the level of the proposer.

If you have a low level, you should stand on a solid foundation and do the work that can be completed with your hands, giving human civilization a little inaccurate force.

If the level is high, the requirements for the pre-research results will be low.

Classic examples, such as the Manhattan Project that made the atomic bomb, were not qualified to propose this idea and hypothesis at the time of Oppenheimer's level. The leader wrote to Roosevelt, who had to be Einstein, so that he could start such a project with nothing and even a little experimental proof.

In fact, it was the scientists from Europe who were working hard to promote this project. They convinced Einstein that they had a letter to Roosevelt.

Otherwise, according to the normal research model, the Manhattan plan can wait for 20 years of pre-research research slowly, and at least wait for someone to make enriched uranium before it can be a foundation for nuclear bombs.

But because it was a state of war and Einstein's appearance, the pre-requisite requirements for the Manhattan plan became lower.

Instead, the project has become bigger.

What Yang Rui is considering is also the question of how big his new project is and how big he can do.

What he wants to do most now is PCR technology.

According to the timeline, the original author of PCR, Muris, should now begin to consider the relevant concepts of PCR.

However, Muris is a famous lazy person, and in a better way, he is free and easy.

Therefore, even with relevant ideas, the development of PCR is not difficult. Muric took more than two years to complete it. It took him more than 1986 years to be considered partially completed, and it will take 1987 to complete it.

It is safer to do PCR now, but Yang Rui only has one unpublished article, and it is no problem to make it, but he is not sure whether he can get the corresponding reputation.

Although the scientific community is a place where results are spoken, the scientific community is a collection of people, and there are many researchers who have received too much praise or have not received the rewards they deserve. Some of them have been recognized and even compensated in the following years, but some may be completely buried in the old paper pile.

Muris himself is indeed very lazy, but the company behind him is not like this. On the contrary, after the company determined the certainty of PCR next year, it has invested a lot of resources, including several outstanding researchers as deputy to Muris.

After thinking about it, Yang Rui decided to seize the advantage first.

Although I don’t have the corresponding reputation, I may not win the Nobel Prize. However, who is sure that I can get the Nobel Prize?

Einstein almost missed the Nobel Prize because of the theory of relativity that year, and eventually had to use the photoelectric effect to give the prize.

A small body like Yang Rui, or a small body like Muris, can win a prize? It really depends on your life.

Since it depends on your life, it is meaningless to suffer.

When Yang Rui thought of this, he began to slowly write out several key points of PCR on paper.

While doing PCR projects, Yang Rui is not going to repeat the steps of Muris back then. To be precise, he cannot repeat the steps of Muris back then.

Because PCR is a layer of window paper after all, it is easy to pierce, but not easy to tear it clean.

Yang Rui didn't want to pierce a hole and then attract a group of wolves.

Although it is likely to fall into scientific research competition again, from Yang Rui's perspective, he still hopes that the later the scientific research competition, the better.

There is no support from a biotech company with assets worth over 100 million yuan behind him.

The ideal way is that when Yang Rui had established an unrivaled advantage, the later competitors would not have large laboratories to compete for the competition for cost-benefit considerations. As for those scientific research apes who always focus on hot spots to do experiments, it is impossible to eliminate them. These scientific research apes are all corrupt, but they will not affect the work of the main laboratory.

"Then, start with the heat-resistant polymerase." Yang Rui's eyes were taken the last step.

Although it is the last step, heat-resistant polymerase is a pre-technology for practical PCR technology and is also a necessary material. It can speed up subsequent research and development and reduce costs.

On the other hand, this is a very critical technology, and related research has been conducted as early as 1973.

Before the PCR technology was released, the technology was not valued because people also knew what it could be used for. The researchers themselves did it out of interest. In 1973, a female international student from Taiwan, at the request of her instructor, successfully isolated the bacteria's high-temperature resistant TaqDNA polymerase, which was found in the hot springs of Huangshi Park as the research object. Yang Rui didn't even know whether she applied for a patent.

At the time, this might have been quite unnecessary, and no one could have thought that this would eventually become a key part of a technology worth $300 million.

However, even if the other party did not register a patent, it would not be possible to register the paper. Yang Rui's brain was so fast that he thought of a new method: find a new thermophilic bacteria as the research object, and use a new method to separate the high-temperature-resistant polymerase.

Two researchers can apply for patents independently by completing their respective research, which is also a conventional means to bypass patent barriers.

Yang Rui then searched for relevant papers in his mind.

Thermophilus bacteria are microorganisms that live in high temperatures. There are many types. Specialized researchers and laboratories do related research. If Yang Rui devotes himself to it without preparation, he may not be able to get out of it for the rest of his life.

He had to find a thermophilic bacteria that had a thorough research, to determine that it could be used for the separation of high-temperature polymerases, and then start related projects.

With the current scale of Huarui Laboratory, it is not qualified to do wild and money-burning trial and error like a top-level laboratory.

More than ten minutes later, Yang Rui wrote the words "Tengchong" heavily on his notes.

The handwriting is black and thick.

The thermophilic anaerobic bacteria in Tengchong Hot Springs is the first extreme thermophilic bacteria found in China. After being discovered in 1998, it was sequenced by Chinese scientists in the whole genome DNA, which has become the first microorganism in China to decipher the genetic code.

In the Chinese biological world, Tengchong Thermophilus bacteria is considered a famous bacteria. Yang Rui has various studies on this microorganism in his mind, such as archaeological chromosomal proteins, new mechanisms for the formation of bacterial spores, and extreme enzymes obtained from isolation...

It is natural to use it to isolate high-temperature resistant polymerases.

"Let's go to the hot springs." Yang Rui suddenly looked up, his eyes lit up.

...
Chapter completed!