Yang Rui first quickly browsed the papers in the sea to make sure that he would not say more, less, or even wrongly.

The development of the biological field is very fast. Unlike other disciplines, the rapidity of the biological field is not only forward changes, horizontal changes, but also changes in the concept itself.

In other words, the same word means this now, and in a blink of an eye, it may be another meaning.

How fast is it? If a doctor in the biology department pursues romance, he accidentally creates an explosion when he proposes to the goddess. He is imprisoned for five years because of an accident. When he comes out, the goddess's child just happens to be in the third year of junior high school. This is not the change part, this is a normal situation. The change part is that the doctor in the biology department is now tutoring the goddess' child. His knowledge is outdated and backward, so he has to give himself a lesson first.

The world changes so quickly.

To compare, the Euro geometry of mathematics was invented more than a thousand years ago. Newton had five axioms when he was in junior high school, and Lu Xun had the same five axioms when he was in junior high school. By the 21st century, Riemann corrected the last one. As a result, it was too difficult. Not to mention that junior high school students did not learn it, undergraduate mathematics students might not necessarily learn it.

Physics, chemistry, and even metallurgy, and architecture are commonly used for knowledge from thousands of years ago, at least hundreds of years ago.

Only biology is the Nobel Prize awarded this year, and the textbook will be revised next year.

However, if you use those advanced words before the mainstream academic community recognizes it, the situation will become extremely interesting.

This two-way choice that Professor Cai carefully prepared may become a huge discussion venue, completely deviating from its original purpose.

Yang Rui thought about it for almost a quarter of an hour before he carefully said: "In fact, before I made the potassium channel, I published several papers. When I was doing the potassium channel project, I also did a few extra small experiments, but I didn't write it in this paper because it was irrelevant, but it was indeed a very good topic."

"Oh? What is it?" Professor Cai was responsible for presiding over the meeting. When he heard Yang Rui talk about the potassium channel, he nodded slightly.

Starting from the potassium channel is the most correct way to do it.

Yang Rui sat upright and said, "It is the study of proteins in the potassium channel. However, it is not the mainstream G protein at present, but the interaction between proteins."

"You keep talking."

"Protein is the basic functional unit of life activities. All physiological reaction changes are inseparable from the interaction between proteins and proteins. When doing the potassium channel project, I found that we not only need to understand the structure and function of individual proteins, but also need to understand the functional process of the internal action of proteins..." Yang Rui paused and explained: "Repeat the structure of the potassium channel may be a simple and clear choice, but just making the structure of the potassium channel will soon have no way out. The grade of papers that can be published will also decrease step by step, but the relationship between proteins is different. In an experiment I did before, I did not find relevant research results. It was just that due to time, I have not carefully compared and formed a paper."

In the last sentence, Yang Rui was just nonsense. He just found some papers. However, interacting proteins are an important correlation study of potassium channels. Yang Rui did read a lot when he was doing the potassium channel project.

Regarding the interaction protein, Professor Cai did not comment, but grabbed Yang Rui's point and asked: "So, the laboratory you lead will not do any project on the structural aspects of potassium channel?"

"It's not that I can't do it at all. If the funds are abundant, I can do some in advance." The biggest difference between leading a laboratory and joining a laboratory is that one is the boss, and coordination and command are more important, and the other is that workers must participate on the spot.

The boss can have multiple laboratories at the same time, and workers usually can only work in one laboratory.

For Yang Rui, if someone is willing to make top papers in his lab, he has no reason to object.

As for guidance, it actually didn't take much time. When he came home during the Chinese New Year, Huang Mao didn't still lie in the laboratory for experiments, and his progress was not affected too much.

A good guide is like poking a window paper. The problem is not how big the force is, but the direction and distance.

Most laboratory leaders only guide papers on guessing. The purpose of raising large groups of experimental dogs is to enable them to realize guessing. Sometimes it is a clever method, and sometimes it can only try and make mistakes stupidly.

However, Yang Rui has done a potassium channel project, so it is easy to provide guidance. Although it is not as easy as the school's chemistry teacher guides students to do standard experiments, it is not much more difficult than walking a dog.

Yang Rui's answer was also recognized by everyone, and many people showed a satisfied expression.

Yang Rui's answer shows that the student's brain is clear, not only his IQ, but also his EQ.

This is a very important point for professors and associate professors who are not familiar with Yang Rui.

The only reason why Yang Rui was able to sit here was that there was an article called "CELL". If he left the potassium channel, his first result, and completely started the work, it would be rootless Ping, and few people would build a laboratory with him.

So far, everyone present has actually considered co-construction of laboratories, and Yang Rui is often placed here.

In everyone's opinion, this is already a great treatment.

As for the independent laboratory that Professor Cai mentioned, it is more like a painting cake. It is much more difficult for Yang Rui to get it than a co-built laboratory.

Even Professor Cai himself was undecided.

In fact, in terms of results and papers, most of the scholars here are not as good as Yang Rui.

The three journals "Cell", "Nature" and "Science" are the Bibles in the field of scientific research. They are hard conditions that cannot be harder. There are no fifty articles published in China a year, and they are divided into the field of biology, but there are no ten articles at all.

Although papers of this digit are basically under the name of top universities or institutions such as the Chinese Academy of Sciences, Peking University or Tsinghua University, after years of accumulation, most professors still have no chance or ability to publish papers in CNS.

For example, Professor Tang Ji, although he has published many papers on SYST-BIOL (system biology) with an impact factor of more than 10.0, CELL is CELL, and SB is always two worlds.

Of course, the papers published by Professor Tang Ji's low influence factors are also due to the times. Most Chinese scholars before the reform and release tend to publish Chinese journals, and the Chinese journals at this time were still alive.

On the other hand, Chinese universities today are not only influencing factors.

However, no matter how you look at it, "CELL" is also a shocking force. If Yang Rui is not a student but a teacher, even if he is a junior assistant who just graduated from his senior year, he is qualified to lead a laboratory independently.

Now it’s three years away, but it’s still hard to make people feel like they are.

However, Professor Cai still gave Yang Rui a chance.

This is already the greatest effort he has made without being influenced by tradition, inertia and secularity.

But for now, Professor Cai doesn't want to ask according to Yang Rui's words, and instead said: "You said you have abundant funds, how much do you think you need?"

"200,000 US dollars, plus 3 million RMB." Yang Rui's own potassium channel project cost more than 600,000 US dollars, and it still hurts when he thinks about it now.

Such projects basically cannot get a penny back, and there is nothing to apply for a patent application. Even the research conducted based on this is still basic. Only technical research that can be applied for a patent can be applied for.

However, just like movies with experimental films, art films and commercial films, most of the things that go for awards and styles are purely lost.

There are still very few projects like PCR that can gain both fame and fortune.

If it weren't for the purpose of accumulating reputation, Yang Rui wouldn't have invested in the papers on potassium channels himself.

In the future, it would be better to throw such research into the national laboratory. It would be better for national taxes to waste scientific research dogs than for official apes to waste.

Dogs are human friends.

Professor Cai was not surprised by the figures proposed by Yang Rui and asked back: "Is it enough? How long will it take?"

"Based on the proficiency of the experiment and luck, three months to half a year, of course, you must be quicker if you have more money."

"What if it is US$100,000, what about RMB 4 million?" Professor Cai didn't think Yang Rui wanted more, but he was still willing to save some foreign exchange.

Yang Rui smiled and said, "No," and said, "Most of the reagents must be imported."

"If you can write such a paper in half a year..." Professor Cai pointed to the "CELL" on the table and said, "I will approve this funding."

"Thank you, Professor Cai, then I'll continue."

"We don't have many laboratories with a funding of US$200,000 and RMB 3 million at a time." Professor Cai reminded Yang Rui.

"I understand." Yang Rui knew that if he reworked the original project, there would definitely be many associate professors and even professors willing to join, because they had a great chance of winning the honors of the first author of CNS or tied for the first author.

But for Yang Rui, the nutritional value of such a laboratory is too low. It may be more difficult than this time if you want a new project next year.

After a little brewing, Yang Rui said again: "Let's talk about protein interactions first. I've learned a little about the detection methods for protein interactions. There are probably several ways to detect protein interactions. I think that after setting up a new laboratory, we can start with the detection methods first."

"Yeah." Professor Cai nodded. The detection method is purely technical, relatively stable, and can also obtain a certain amount of results.

Yang Rui cleared his throat and said, "What I think can be done is, first, protein affinity chromatography; second, affinity blotting; third, co-immunoprecipitation; fourth, glutathione transferase precipitation experiment; fifth, chemical crosslinking method; sixth, fluorescence resonance energy transfer method..."

When we talked about this, the professors who were originally listening to Yang Rui's words were slowly earnest.

It is just a list of detection methods, so many people present can do it, it is nothing more than memorizing or memorizing. If there are some amazing people, they can still remember them at a glance, let alone.

However, Yang Rui's skillful listing shows that at least he did not speak nonsense.

Under the attention of everyone, Yang Rui said three without any fright: "Seventh, surface plasmon resonance technology; eighth, phage display technology; ninth, yeast two-hybrid or multi-hybrid..."

When it comes to the seventh time, many people, including Professor Fu, have become unnatural. The reason is very simple, they have heard of the noun, but they don’t understand the specific content.

Professor Fu immediately raised an objection and said, "What you just said is what the new laboratory can do, and all these tests can be done?"

The detection method is not only a detection method, but also a more advanced detection method, but often represents more accurate and fresher conclusions. When implemented, it means more and better papers.

This is much more meaningful than the meaning of illusory proteins.

When Yang Rui was studying, these detection methods were not new. They were things that ordinary laboratories had. He didn't talk nonsense and said directly: "Surface plasmon resonance technology obtains specific signals of biological molecules' interactions through dynamic changes in the SPR angle, that is, the resonance angle during biological reactions. It is also very convenient to use a computer and accompanying software to analyze the ligands on the chip and the molecules to be tested, which are used to detect the interaction between antigens and antibodies, receptors and ligands, proteins and nucleic acids, proteins and small molecules."

Professor Fu opened his mouth and had no way to refute it. Because he didn't understand, he could only look at both sides as if he wanted help.

Lu Yueping, who once recommended Xu Anqing to Richard, couldn't see it, and coughed, saying, "The principle of surface plasmon resonance technology is that it is true. I used it when I visited the UK. However, the computer technology used is still relatively complicated. Can you do it?"

"I have used similar computers, and they are available in Huarui Laboratory. If you are interested, I can demonstrate them on the spot." Yang Rui didn't say anything. Although the computers are complicated today, Yang Rui doesn't find it very difficult to learn them. In fact, the academic special software in later generations is not simple. The wonderful human-computer interaction and friendly interface have never been a scientific research dog.

But everyone was in awe of the people. Nowadays, just using applied computers to do experiments is already very academic.

Professor Cai was also slightly moved. Yang Rui's youth seemed to have become an advantage at this time.
Chapter completed!