Chapter 371 Success is imminent!(1/4)
This sudden discovery made Chen Nan suddenly excited.
XIAP-related adult single-gene mutant Crohn's disease is of great clinical significance.
It may even be related to the triggers for patients with Crohn's disease.
Chen Nan instantly figured out the ideas and clues for the next research, as well as the follow-up research plan.
First of all: how to use Chinese medicine orally to alleviate the triggering factors of the disease and prevent the development and worsening of the disease. It can also be used with concentrated Chinese medicine enema and external drugs to treat intestinal inflammation that has already formed.
Secondly: For patients who are at risk of Crohn's disease, perform gene sequencing, then find the XIAP gene, and use traditional Chinese medicine to prevent the disease from occurring and achieve the purpose of preventing the disease before it occurs.
However, no matter which one, it is absolutely of great significance to the patient.
The most important factor in Crohn's disease is the procrastination of cure. If more targets can be found based on the already discovered XIAP gene, this may be useful in treating Crohn's patients or the recurrence of the disease. There is a significant effect.
Chen Nan knows very well that Crohn's disease, like diseases such as hypertension, is not a problem that can be solved by current medical standards.
When Sun Jinxiao heard the sound, his eyes widened. After thinking for a moment, he nodded: "I have learned a lesson!"
"You have an X-linked inhibitor of apoptosis protein (XIAP) gene mutation on your X chromosome. XIAP gene mutations induce inflammatory bowel disease through defects in innate immune function of intestinal immune cells."
"But before that, I have something to tell you."
"Of course, you can rest assured that after we join, we will also bring relevant staff for clinical cooperation. Our nurses and doctors have all received professional training."
"So, I studied it based on the traditional Chinese medicine circle movement and the thinking of five movements and six qi."
And Sun Jinxiao will definitely prove his early treatment concept by joining him.
Sun Jinxiao was stunned for a moment by Chen Nan's words: "What do you mean?"
Chen Nan shook his head: "XIAP-linked apoptosis inhibitory protein mutation is my latest discovery. There has been no large-scale research yet."
"I won't hold you back!"
Sun Jinxiao heard this and waved his hands to Chen Nan and Zhao Jianyong: "Director Chen, there is no need to drink water. If I am here to drink tea or do other things, there is no need for it."
"Am I hopeless?"
Xu Maoxuan was also stunned at this time.
Everyone looked at Chen Nan with wide eyes, their eyes full of disbelief.
He knew that the Department of Gastroenterology in the Western Medicine Ward was a national key specialty with a very high level. As the director, how could Sun Jinxiao's level be any worse?
So... Chen Nan still didn't understand, but still said politely:
Qin Shiming can be said to be refreshed, they have such a good opportunity!
Chen Nan smiled: "I'm sure!"
Sun Jinxiao said calmly: "Maoxuan, what we are looking for is a like-minded partner, not a colleague who seems to be incompatible but distant."
Sun Jinxiao didn't expect Chen Nan to call so quickly and said: "I'm not busy."
“Traditional Chinese medicine’s understanding of diseases, in addition to innate endowment, pays attention to internal and external causes.”
Chen Nan looked at Xue Zhongqing on the side: "Director Xue, please introduce me to Director Sun."
"Director Chen, thank you for letting me join your research group."
"Director Sun, do you need me to continue?"
But he also knew that for cursed people like him, how could this disease get better so easily?
Undoubtedly, the above do not agree with Sun Jinxiao's view.
If I don’t have strong strength, why should I need you?
After saying that, Sun Jinxiao took Xu Maoxuan and left directly without paying any attention to what he left behind for Chen Nan.
What Chen Nan just found was a special project application report.
"These patients have congenital immune deficiencies at the same time, and it is due to a single gene mutation."
"Director Sun is very capable. He has been engaged in clinical work for more than 30 years and has participated in research on inflammatory bowel diseases many times, but... rarely wins awards."
Sun Jinxiao remained silent. What a joke? Sun Jinxiao never thought that he had done anything wrong.
This time, in order to prevent favoritism and malpractice, he personally came to supervise.
Mitchell was silent for a moment.
"He is also the second person in charge of our research work."
Although the use of biological agents, represented by anti-tumor necrosis factor (TNF), has changed the clinical outcomes of some patients, more than half of the patients still require surgical intervention, and 50% of patients experience clinical recurrence after surgery.
,80% had endoscopic recurrence and 30% had surgical recurrence.
Not long after!
Sun Jinxiao and Xu Maoxuan arrived at the Crohn's Disease Research Center of the Integrated Traditional Chinese and Western Medicine Ward.
Only after Sun Jinxiao gets a satisfactory answer will he decide whether to be the second person in charge.
"Obviously, I got accurate information here."
"This kind of floating pulse is a superficial syndrome, but the patient does not seem to be infected with external evils."
Xu Maoxuan sighed: "Director Sun, I think... you are too honest. You even gave Chen Nan the original rejection of the professional committee."
Chen Nan looked through these materials and planned to put them in the office. He would read them later and go to the ward for rounds first.
To be honest, Chen Nan was instinctively excited that Sun Jinxiao could come up with such a new concept.
Zhao Jianyong nodded: "Okay!"
Sure enough, when Chen Nan saw the experts' feedback at the end of the project, he saw the words "disagree" and "negative".
At this time, Chen Nan placed his hand on Mitchell's wrist again, and then observed his tongue.
Chen Nan nodded: "Well, we will start treatment next."
Then, Chen Nan looked at Mitchell: "Mr. Mitchell, you must remember the changes in symptoms every day, we need you!"
"Our work needs to begin, and you have a lot to do."
Mitchell's eyes widened immediately: "Dr. Chen, don't you worry about this..."
Chen Nan summoned Zhao Jianyong and others and came to the office.
"Today's visit is not for other reasons, but because we want to join your Crohn's Disease Research Center."
Chen Nan was instantly attracted by these words.
He never thought that Chen Nan, who was misunderstood by everyone and even laughed at by countless people at this moment, would discover such an important clue.
"This is……"
Sun Jinxiao shook his head excitedly: "No need!"
"So, I considered at that time whether there was a genetic defect. This so-called genetic defect was a lack of innate endowment."
…
"Early treatment should be carried out in stages and according to the situation."
Sun Jinxiao shook his head: "No, it's different."
Perhaps in the eyes of others, Sun Jinxiao is older than Yan Jiaheng and others, but he does not rise as fast as others.
"We are applying to join, and we need to come with sincerity and ability. If Director Chen comes and directly welcomes me, not only will I not be happy, I will only feel a little worried. After all... a strict research group must be almost harsh in personnel control.
.”
While talking, he stood up and entered the room holding Sun Jinxiao's information.
I can only say that the current level, the level of professional committees, is not necessarily high.
"Director Chen, you mean...the significance of early treatment is to conduct genetic testing of Crohn's disease patients in advance, and provide timely intervention and treatment for patients with XIAP-related adult single gene mutations?"
This is the opinion of experts.
…
Before Zhao Jianyong had time to speak, the man on the side walked over decisively and introduced himself.
"We have been studying for a long time..."
“If you don’t understand it or don’t like it, we’ll do it ourselves!”
"Besides, maybe we can find something special too?"
In fact, early treatment is very difficult because the onset of Crohn's disease is mostly insidious, and it often takes months to years from the onset of early symptoms to diagnosis.
Why……
After Chen Nan opened it, he looked at it carefully.
Xue Zhongqing nodded: "Actually, Director Sun's reputation in the hospital is very good, and this person rarely asks for help. To be honest, I am also curious why Director Xue would take the initiative to apply to join."
I will define the definition of early treatment, evaluate its clinical benefits and risks, and further analyze the research elements based on the research progress of CD in recent years to provide reference for domestic colleagues."
"Director Sun, this is your next job."
To be continued...