Late at night, Sanqing R&D Building.

Wen Renlong stretched, yawned loudly, opened the office door, and walked out.

His hair was as messy as a bird's nest, his messy shirt was stained with a few suspicious stains and emitted a peculiar smell, his eye sockets were sunken into large dark circles, and he looked haggard and tired.

There was only one pair of eyes, but they were still bright and energetic, showing no signs of fatigue.

He strode toward the biology laboratory downstairs and came to a brightly lit office. He seemed a little tired and was too lazy to reach out. He flew over with a skillful kick and kicked open the ajar door.

"What's the matter?" Tang Que asked without raising his head. As soon as he heard the noise, he knew that there would be no one else except Wen Renlong.

Wen Renlong walked in excitedly, stared at Tang Que with stern eyes, stretched out two fingers and made a V sign.

"The r5 antagonist has finally achieved a qualitative breakthrough."

"After three days and three nights of my non-stop efforts, this medicine was completed."

"Oh?" Tang Que suddenly became interested and stretched out his hand: "Show me."

Wen Renlong took out a tablet from his pocket, clicked it a few times, handed it over, and introduced it eloquently.

"The r5 antagonist has high affinity. The conformation of 1, 2, 3 of r5 and the extracellular region of r5 can effectively antagonize the induction of rantes."

"In vivo experiments in rodents and primates have shown that its oral bioavailability is 70%, its plasma half-life is 8 hours, and the replication of the r5 virus strain is significantly reduced."

"However, in subsequent animal experiments and in the derivation of aicell's clinical trials, it was found that it will cause certain damage to the kidneys at high concentrations, and long-term use can lead to adverse reactions such as renal failure."

"So I used AI modeling to structurally modify it and obtained a series of compounds. I obtained a derivative small molecule antagonist sqw26746, which has 20 times higher antagonistic activity than sqw1385."

"The current derivation in aicell shows that sqw26746 has up to 10 times the biological activity without adverse reactions such as kidney damage. It has good pharmacokinetic properties, 100% bioavailability, and a drug binding rate of up to 90%.

It will not cause an inhibitory reaction to liver enzymes and will not cause hepatotoxicity."

"In vitro activity experiments have also proven this. In animal experiments on genetically modified mice and monkeys, this drug has a very strong inhibitory effect on the HIV virus."

"Although the data of this drug seems to be perfect, the 90% binding still does not meet my high standard of 100%."

Wen Renlong's smug tone suddenly changed and he spoke casually.

"Fortunately, with your help, we added a large peptide antagonist. This is a short peptide containing 41 amino acids with extremely high affinity. R5 blocks the activity of the HIV virus."

"Although it is not very stable, after adding an auxiliary agent, it can already take effect through oral administration, perfectly complementing sqw26746, and achieving a 100% high binding rate."

"At the same time, I also added other inhibitors to it, which can have a comprehensive killing effect on the replication and spread of the HIV virus."

"I named this new anti-HIV drug Jueqing Jue Ling. If you take it, you can stop love and love. All evil will not invade you, and you will be reborn in Nirvana."

Tang Que listened carefully at first, but at the end, he couldn't hold back and burst out laughing.

"Have you read too much and become confused? Can you give me a more normal name?"

Wen Renlong thought seriously for a second and said, "The name Jueqing Duan Ailing is a bit long, so let's call it Duan Ailing."

"I quite like this name. It's very interesting. It will definitely be easy to remember. Didn't the boss promise us that we can have the naming rights for the drugs we develop ourselves? He shouldn't refuse me."

Tang Que twitched the corner of his mouth, spread his hands and said: "Anyway, the drug has three names. The chemical name and common name are standardized, so you can't mess around with it. We only decide the trade name ourselves, so it's not up to you."

Wen Renlong pouted and said: "I have developed such an awesome drug, so I must have the right to name it, otherwise I will not be willing to do so. Since I want everyone to know that I developed this drug, the name must have a personal style and

It’s unique, how can it not be more fashionable?”

"What about bevacizumab, osimertinib, telmisartan, dexamethasone, isopyrazole hydrochloride, and omeprazole? Who else except us can remember these names?"

"What is dexamethasone? Do you believe that the patient can call it tiramisu for you?"

"How could it be as good as my Love-Breaking Spirit? It's catchy and easy to understand."

Tang Que said angrily: "Please, wasn't sqw26746 named by you? Isn't that w the first letter of your name?"

"Tch, this is just an internal code name. Except for the hard disk, no ghost can remember it." Wen Renlong said plausibly.

A drug usually has multiple different names from development to marketing.

During the research and development stage, the drug will have a code name used to represent the compound, such as sqw26746. Sometimes it is simply called 26746 to save trouble. This is equivalent to the nickname of a child who has not been born, as long as his family can distinguish it clearly.

After successful research and development, the drug will have a common name, which is the legal name of the drug approved by the State Food and Drug Administration. This is equivalent to the official name on the child's ID card. Various common drug names in hospitals that are not clear and powerful fall into this category.

.

When it is put on the market, pharmaceutical companies will give the drug a trade name, such as Ganmaotong, Changchongqing and other easy-to-understand names.

Patients usually call the drug by its brand name, because unless it's a familiar name like ibuprofen or aspirin, the generic name is too clumsy and difficult to understand.

That's why Wen Renlong was so concerned about choosing a popular name and putting his own brand on it.

After all, the market for anti-AIDS drugs is extremely broad, and it is easy to produce a hit product that is famous all over the world. Cocktail therapy is famous for being easy to understand.

Thinking that the name "Broken Love Spirit" was about to spread all over the world, he couldn't help but feel itchy in his heart, and his whole body felt as if it had been electrified and felt extremely comfortable.

Snap!

Tang Que didn't bother to talk to him anymore. He lazily raised his hands and clapped, interrupting his reverie.

"Oh, Aaron, you are so outstanding. An outstanding man like you is like a firefly in the dark, no matter where he is, so bright and outstanding."

Wen Renlong immediately held his head high and said, "Call me Brother Long."

Tang Que's breath suddenly suffocated, and his teeth felt a little itchy.

He suddenly stretched out his right hand, waved it under his nose, frowned and asked.

"What does this smell like? Why is it so smelly? You just said you stayed up for several nights? Did you never take a shower? This is too sloppy."

Wen Renlong said sarcastically: "Can scientists be called sloppy? Brother Que, I'm so sleepy. I have to go back and catch up on my sleep. I'll have enough energy to report to the boss tomorrow."

"I'm leaving first. Don't try to keep me here. I know you're interested, but I really don't have time. If you want to know more details, ask me tomorrow."

Wen Renlong waved his hand quickly, turned around and left, disappearing outside the door in an instant.

Tang Que shook his head and turned his eyes to the computer.

The successful development of r5 antagonists undoubtedly put a certain amount of pressure on him.

He has not forgotten that the two people's research and development routes were in a competitive relationship at the beginning. Now that the brother has achieved results, he is happy, but the sense of urgency in his heart is also stronger.

"It is really difficult to knock out the inserted HIV gene fragment from the patient's DNA."

"After the HIV virus enters the human body, it will quickly replicate in large quantities, infect all cells in the body, and lurk everywhere in the body. After the HIV virus in the immune system is eliminated, it will reappear, copy out of the body cells, and continue to relapse.

Endless."

"This is a very cunning virus that is difficult to eliminate completely."

"Ordinary genetic drugs can only be treated continuously, but they can never cure the disease. The costs are huge for both patients and pharmaceutical companies. They are not as cheap and easy to use as antagonists."

"The boss's idea is good, and the idea provided by Aaron is also correct, but I have only developed genetic drugs to knock out HIV virus gene fragments. How can I wrap the drug in a viral plasmid and deliver it to the whole body?

A tough conundrum.”

"The most difficult thing is to select a suitable virus that can not only infect cells throughout the body, but can also be modified so that it removes its toxicity while retaining its infectivity and not causing harm to the human body."

"The most suitable one in this regard is cold virus, which can be included as a candidate. Let's take a look at the other ones."

"The current situation is equivalent to that I already have a fatal bullet, but I lack a powerful gun that can send the bullet thousands of meters away to destroy the enemy without affecting my health."

"After making bullets, let's continue to study how to make guns. No matter how difficult it is, you have to master it."

"You can't say you're not good at something you agree to in front of your boss."

Tang Que was murmuring in his heart, looking at the computer screen and lost in thought.

****

The next day, Wei Kang learned about the successful development of anti-AIDS drugs in the office and was immediately excited.

This is the biggest good news before the Spring Festival.

The HIV virus is currently the most difficult virus to kill in the world. None of the currently known therapeutic drugs have the function of killing the HIV virus. They are only inhibitors.

The best result of long-term use of such drugs is to keep the virus in the latent stage and the patient becomes a carrier. Once resistance or intolerance develops, the latent stage may turn into a real AIDS patient at any time.

Although pharmaceutical companies continue to introduce new products, patients' survival time is getting longer and longer.

But the pain of having to take medication for life is still tormenting every patient.

The main reason is that the drugs in cocktail therapy have serious side effects, and taking medicine every day is also a hassle.

If the patient goes out to socialize, travel, or do errands, it will be very inconvenient for him to take medicine.

This disease has a very bad reputation, unlike anti-inflammatory drugs and health care products that can be widely advertised.

If you go out to eat and bring a box of cephalosporins, everyone will definitely look at you with caring eyes. Not only will you receive a wave of condolences, but it will also block everyone from coming to toast.

But if you take anti-AIDS medicine with you when you go out to eat, there is a high probability that everyone will run away and we will no longer be friends. They will hide from you when they see you in the future, and your reputation will be bad.

Therefore, most AIDS patients take medicine secretly and do not dare to let others know, which causes great trouble in their daily life.

For these people, AIDS is like a shackles, and the patients are trapped between these shackles every day and cannot escape.

Once you stop taking the medicine, you will face a crazy rebound of the virus.

It is like a devastating disaster to myself and my family.

The disease has spread around the world, especially in the liberal West and the Philippines, where it originated.
To be continued...